期刊
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
卷 18, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/ijerph182211741
关键词
Fusarium; fusariotoxins; mycotoxins; free; emerging; masked; food safety; health impacts
资金
- National Research Foundation of South Africa (NRF) [116643]
- North-West University, South Africa (NWU)
The genus Fusarium produces various mycotoxins, including trichothecenes, fumonisins, and zearalenone. These mycotoxins can cause acute or chronic illness, and even death, in humans and animals after consuming contaminated grain. The metabolic fate of masked Fusarium mycotoxins remains a subject of scientific discussion.
The genus Fusarium produces a number of mycotoxins of diverse chemical structures. Fusariotoxins are secondary metabolites produced by toxigenic fungi of the genus Fusarium. The important and commonly encountered fusariotoxins are trichothecenes, fumonisins, and zearalenone. Fusarium mycotoxins pose varying toxicities to humans and/or animals after consumption of contaminated grain. They can cause acute or chronic illness and, in some cases, death. For instance, a range of Fusarium mycotoxins can alter different intestinal defense mechanisms, such as the epithelial integrity, cell proliferation, mucus layer, immunoglobulins, and cytokine production. Of recent concern is the occurrence of emerging and masked Fusarium mycotoxins in agricultural commodities, which may contribute to toxic health effects, although the metabolic fate of masked mycotoxins still remains a matter of scientific discussion. These mycotoxins have attracted attention worldwide because of their impact on human and animal health, animal productivity, and the associated economic losses. In this paper, we review Fusarium mycotoxins and their metabolites with the aim of summarizing the baseline information on the types, occurrence, and health impacts of these mycotoxins in order to encourage much-needed research on integrated management of this unavoidable food contaminant as concerns for food safety continues to grow worldwide.
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