期刊
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
卷 74, 期 -, 页码 145-151出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2016.03.002
关键词
Redox signaling; NADPH oxidase; Heart failure; Reactive oxygen species
资金
- British Heart Foundation
- Foundation Leducq Transatlantic Network of Excellence Award
- Department of Health via a National Institute for Health Research (NIHR) Biomedical Research Centre
- King's College London and King's College Hospital NHS Foundation Trust
- British Heart Foundation [RG/13/11/30384] Funding Source: researchfish
The specific effect of oxygen and reactive oxygen species (ROS) in mediating post-translational modification of protein targets has emerged as a key mechanism regulating signaling components, a process termed redox signaling. ROS act in the post-translational modification of multiple target proteins including receptors, kinases, phosphatases, ion channels and transcription factors. Both O-2 and ROS are major source of electrons in redox reactions in aerobic organisms. Because the heart has the highest O-2 consumption among body organs, it is not surprising that redox signaling is central to heart function and pathophysiology. In this article, we review some of the main cardiac redox signaling pathways and their roles in the cardiomyocyte and in heart failure, with particular focus on the specific molecular targets of ROS in the heart. (C) 2016 Elsevier Ltd. All rights reserved.
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