期刊
出版社
MDPI
DOI: 10.3390/ijerph19020694
关键词
polychlorinated biphenyls; congeners; birth weight; prenatal exposure
资金
- Japan Society for the Promotion of Science (JSPS) [16H01781, 18K18199]
- Department of Environmental Preventive Medicine (Yamada Bee Company, Okayama, Japan)
- Yamada Bee Company, Inc
- Environment Research and Technology Development Fund of Ministry of the Environment (MoE), Japan [5-1652]
- Grants-in-Aid for Scientific Research [18K18199] Funding Source: KAKEN
In this study, the effects of PCB congener exposure on birth weight were examined. The results showed that exposure to PCB mixtures is associated with low birth weight, but specific impacts of individual PCB congeners on birth weight could not be determined.
Maternal exposure to polychlorinated biphenyls (PCBs) during pregnancy is associated with a low birth weight; however, the congener-specific effects of PCB congeners are not well defined. In this study, we used maternal serum samples from the Chiba Study of Mother and Child Health (C-MACH) cohort, collected at 32 weeks of gestational age, to analyze the effects of PCB congener exposure on birth weight by examining the relationship between newborn birth weight and individual PCB congener levels in maternal serum (n = 291). The median total PCB level in the serum of mothers of male and female newborns at approximately 32 weeks of gestation was 39 and 37 ng g(-1) lipid wt, respectively. The effect of the total PCB levels and the effects of PCB congener mixtures were analyzed using a linear regression model and a generalized weighted quantile sum regression model (gWQS). The birth weight of newborns was significantly associated with maternal exposure to PCB mixtures in the gWQS model. The results suggest that exposure to PCB mixtures results in low newborn birth weight. However, specific impacts of individual PCB congeners could not be related to newborn birth weight.
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