期刊
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
卷 18, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijerph182111537
关键词
Schistosoma haematobium; reinfection rate; incidence; mass drug administration; Sudan
资金
- Korea International Cooperation Agency (KOICA) [P-2015-00145]
This study investigated the reinfection rate of urogenital schistosomiasis in school-aged children in the White Nile State of Sudan after mass drug administration (MDA). The results showed that the reinfection rate was significantly higher in high-infection areas compared to low-infection areas, with 41% of cases in high-infection areas attributed to reinfection. Efforts should focus on developing targeted treatment strategies to track high-risk groups within schools or communities.
The reinfection rate of schistosomiasis after mass drug administration (MDA) has not been documented in Sudan. We aimed to explore the transmission dynamics of urogenital schistosomiasis after MDA, targeting school-aged children in the White Nile State of Sudan, assessing the prevalence, reinfection rate, and incidence. A single dose of praziquantel (40 mg/kg) was administered to 1951 students in five primary schools from January to February 2018 immediately after a baseline survey, and follow-up surveys were performed at 2 weeks and 6 months after treatment. We examined Schistosoma haematobium eggs by centrifugation methods. The overall reinfection rate at 6 months after treatment was 9.8% (95% confidence interval: 0.5-17.4%). By school, the reinfection rate was highest in the Al Hidaib school, whose prevalence was highest at baseline. The reinfection rate was significantly higher in high-infection areas than low-infection areas (p = 0.02). Of the prevalence at 6 months in high-infection areas, 41% of cases were due to reinfection. MDA interventions are decided upon and undertaken at the district level. A more targeted treatment strategy should be developed with a particular focus on tracking high-risk groups, even within a school or a community.
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