期刊
出版社
MDPI
DOI: 10.3390/ijerph19031228
关键词
chemical-mediated interactions; ecological interaction network; microbiome; exometabolome; mediator-explicit model; interaction network inference; microbial time series
Network-based assessments are crucial for understanding complex microbial and microbial-host interactions, and are essential for microbial engineering. Chemical-mediated interactions play a significant role in the coexistence of microbial species. However, the effectiveness of existing methods in detecting chemical-mediated interactions remains uncertain.
Network-based assessments are important for disentangling complex microbial and microbial-host interactions and can provide the basis for microbial engineering. There is a growing recognition that chemical-mediated interactions are important for the coexistence of microbial species. However, so far, the methods used to infer microbial interactions have been validated with models assuming direct species-species interactions, such as generalized Lotka-Volterra models. Therefore, it is unclear how effective existing approaches are in detecting chemical-mediated interactions. In this paper, we used time series of simulated microbial dynamics to benchmark five major/state-of-the-art methods. We found that only two methods (CCM and LIMITS) were capable of detecting interactions. While LIMITS performed better than CCM, it was less robust to the presence of chemical-mediated interactions, and the presence of trophic competition was essential for the interactions to be detectable. We show that the existence of chemical-mediated interactions among microbial species poses a new challenge to overcome for the development of a network-based understanding of microbiomes and their interactions with hosts and the environment.
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