期刊
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
卷 12, 期 2, 页码 210-216出版社
WILEY
DOI: 10.1002/alr.22902
关键词
ageusia; COVID-19; gustation; smell; taste
资金
- EXU-transcelerator B3 grant, TUDresden
Subjective impairment of taste is a common symptom of COVID-19, reported in around 50% of cases, but psychophysical testing shows a lower prevalence of 26% due to misinterpretation of olfactory dysfunction. Researchers hypothesize that COVID-19-related hyposmia may contribute to the decrease in gustatory function, requiring further investigation.
Subjectively perceived impairment of taste is a common and distinct symptom of coronavirus disease 2019 (COVID-19). Large meta-analyses identified this symptom in approximately 50% of cases. However, this high prevalence is not supported by blinded and validated psychophysical gustatory testing, which showed a much lower prevalence in up to 26% of patients. This discrepancy may be due to misinterpretation of impaired retronasal olfaction as gustatory dysfunction. In addition, we hypothesized that COVID-19-associated hyposmia is involved in the decrease of gustatory function, as found for hyposmia of different origin. This indirect mechanism would be based on the central-nervous mutual amplification between the chemical senses, which fails in COVID-19-associated olfactory loss. However, further research is necessary on how severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) may directly impair the gustatory pathway as well as its subjective perception.
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