期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2021.791532
关键词
Parkinson's disease; sex differences; magnetic resonance imaging; gray matter atrophy; cognitive impairment
资金
- Spanish Ministry of Economy and Competitiveness [PSI2017-86930-P]
- Agencia Estatal de Investigacion (AEI)
- European Regional Development Fund (ERDF) [PID2020-114640GB-I00/MCIN/AEI/10.13039/501100011033]
- Generalitat de Catalunya [2017SGR748]
- Maria de Maeztu Unit of Excellence (Institute of Neurosciences, University of Barcelona), Ministry of Science, Innovation and Universities [MDM-2017-0729]
- Spanish Ministry of Science, Universities and Research
- European Social Fund [PRE2018-086675]
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie fellowship [888692]
- APIF predoctoral fellowship from the University of Barcelona
- Michael J. Fox Foundation for Parkinson's Disease (MJFF) [MJF_PPMI_10_001, PI044024]
- Marie Curie Actions (MSCA) [888692] Funding Source: Marie Curie Actions (MSCA)
A study found that there are differences in symptoms, brain structure and cognitive function between male and female PD patients. Compared to females, male patients had more severe symptoms, greater brain atrophy, and worse cognitive function.
Background and Objective: Brain atrophy and cognitive impairment in neurodegenerative diseases are influenced by sex. We aimed to investigate sex differences in brain atrophy and cognition in de novo Parkinson's disease (PD) patients.Methods: Clinical, neuropsychological and T1-weighted MRI data from 205 PD patients (127 males: 78 females) and 69 healthy controls (40 males: 29 females) were obtained from the PPMI dataset.Results: PD males had a greater motor and rapid eye movement sleep behavior disorder symptomatology than PD females. They also showed cortical thinning in postcentral and precentral regions, greater global cortical and subcortical atrophy and smaller volumes in thalamus, caudate, putamen, pallidum, hippocampus, and brainstem, compared with PD females. Healthy controls only showed reduced hippocampal volume in males compared to females. PD males performed worse than PD females in global cognition, immediate verbal recall, and mental processing speed. In both groups males performed worse than females in semantic verbal fluency and delayed verbal recall; as well as females performed worse than males in visuospatial function.Conclusions: Sex effect in brain and cognition is already evident in de novo PD not explained by age per se, being a relevant factor to consider in clinical and translational research in PD.
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