期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2022.805063
关键词
EEG; Alzheimer's disease; animal models; mice; non-human primate; biomarkers
资金
- NIH [U54 AG05434503, 1R01AG067289-01]
Emerging data suggest that sub-clinical, non-convulsive epileptiform activity is prevalent in Alzheimer's disease (AD) and can be detected early in the disease. It is also correlated with cognitive decline in both humans and animal models. Epileptiform activity and electroencephalographic (EEG) measures have untapped potential to enhance the translational validity of AD-related biomarkers in animal models.
Continually emerging data indicate that sub-clinical, non-convulsive epileptiform activity is not only prevalent in Alzheimer's disease (AD) but is detectable early in the course of the disease and predicts cognitive decline in both humans and animal models. Epileptiform activity and other electroencephalographic (EEG) measures may hold powerful, untapped potential to improve the translational validity of AD-related biomarkers in model animals ranging from mice, to rats, and non-human primates. In this review, we will focus on studies of epileptiform activity, EEG slowing, and theta-gamma coupling in preclinical models, with particular focus on its role in cognitive decline and relevance to AD. Here, each biomarker is described in the context of the contemporary literature and recent findings in AD relevant animal models are discussed.
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