Mechanisms Regulating T Cell-Endothelial Cell Interactions

T-cell interaction with the endothelial cells lining the vessel wall is a necessary step in the inflammatory response that allows T cells to extravasate from the circulation and migrate to sites of infectious or sterile inflammation. On one hand, the vascular endothelium is activated and, as a result, switches from an anti-adhesive to a pro-adhesive state, allowing adhesion of T cells and other leukocytes. On the other hand, T cells express ligands of endothelial adhesion molecules to sustain these interactions that eventually result in T-cell extravasation into sites of inflammation. A better understanding of the central players mediating these interactions may help develop novel therapeutics that modulate this process by preventing T-cell migration and inflammation. Here, I summarize current knowledge on the nature of these interactions in the context of inflammation and cancer immunotherapy.

Automated summary

T-cell interaction with endothelial cells plays a crucial role in the inflammatory response, allowing T cells to migrate from the circulation to sites of infection or sterile inflammation. Understanding the key players in these interactions may lead to the development of novel therapeutics that can modulate T-cell migration and inflammation.