期刊
CELL REPORTS
卷 37, 期 6, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109972
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资金
- NIH BRAIN Initiative [U01NS094247, R01NS104944, RF1MH120119]
- NINDS [R01NS081071, R21NS097856]
- Simons Foundation
- James S. McDonell Foundation
- NSF
Cortical function relies on balanced activation of excitatory and inhibitory neurons. The organization and dynamics of shaft excitatory synapses onto cortical inhibitory interneurons are not well understood. Studies show that synapses onto PV+ neurons are less variable and more stable.
Cortical function relies on the balanced activation of excitatory and inhibitory neurons. However, little is known about the organization and dynamics of shaft excitatory synapses onto cortical inhibitory interneurons. Here, we use the excitatory postsynaptic marker PSD-95, fluorescently labeled at endogenous levels, as a proxy for excitatory synapses onto layer 2/3 pyramidal neurons and parvalbumin-positive (PV+) interneurons in the barrel cortex of adult mice. Longitudinal in vivo imaging under baseline conditions reveals that, although synaptic weights in both neuronal types are log-normally distributed, synapses onto PV+ neurons are less heterogeneous and more stable. Markov model analyses suggest that the synaptic weight distribution is set intrinsically by ongoing cell-type-specific dynamics, and substantial changes are due to accumulated gradual changes. Synaptic weight dynamics are multiplicative, i.e., changes scale with weights, although PV+ synapses also exhibit an additive component. These results reveal that cell-type-specific pro
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