4.8 Article

Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria

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CELL REPORTS
卷 37, 期 5, 页码 -

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CELL PRESS
DOI: 10.1016/j.celrep.2021.109956

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  1. NIH [P30 CA086862, AI42767, AI985515, AI100527, AI114543, A125446, A127481, GM134880, T32 HL007, T32 AI007511, T32 AI007343, T32 AI007485]

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The study shows that effector memory CD8 T cells rapidly infiltrate the liver after malarial infection, mediating pathogen clearance through upregulation of inflammatory genes. This highlights the crucial role of Tem in protecting against malaria infection.
Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the liver within 6 hours after malarial or bacterial infections and mediate pathogen clearance. Tem recruitment coincides with rapid transcriptional upregulation of inflammatory genes in Plasmodium-infected livers. Recruitment requires CD8 T cell-intrinsic LFA-1 expression and the presence of liver phagocytes. Rapid Tem liver infiltration is distinct from recruitment to other non-lymphoid tissues in that it occurs both in the absence of liver tissue resident memory sensing-and-alarmfunction and -42 hours earlier than in lung infection by influenza virus. These data demonstrate relevance for Tem in protection against malaria and provide generalizable mechanistic insights

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