期刊
CELL REPORTS
卷 38, 期 5, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2022.110307
关键词
-
类别
资金
- National Institutes of Health [R01 EY024884, R21 EY032392, R01 EY021146, F32 EY024184, T32 NS007484, T32 EY024234]
- Edward R. and Anne G. Lefler Center
- Leonard and Isabelle Goldenson Fellowship
- Alice and Joseph Brooks Fund Postdoctoral Fellowship
- Beca de Postdoctorado en el Extranjero -Becas Chile
- Loreen Arbus Scholarship
- Stuart H.Q. & Victoria Quan Fellowship
The polarized flow of information in neural circuits relies on the organization of neurons, their processes, and their synapses. Fat3, a protein similar to Fat cadherins, plays a crucial role in the development of polarized circuits in the mouse retina. It binds to cytoskeletal regulators and synaptic proteins, coordinating different cell behaviors and regulating synapse localization.
The polarized flow of information through neural circuits depends on the orderly arrangement of neurons, their processes, and their synapses. This polarity emerges sequentially in development, starting with the directed migration of neuronal precursors, which subsequently elaborate neurites that form synapses in specific locations. In other organs, Fat cadherins sense the position and then polarize individual cells by inducing localized changes in the cytoskeleton that are coordinated across the tissue. Here, we show that the Fat-related protein Fat3 plays an analogous role during the assembly of polarized circuits in the murine retina. We find that the Fat3 intracellular domain (ICD) binds to cytoskeletal regulators and synaptic proteins, with discrete motifs required for amacrine cell migration and neurite retraction. Moreover, upon ICD deletion, extra neurites form but do not make ectopic synapses, suggesting that Fat3 independently regulates synapse localization. Thus, Fat3 serves as a molecular node to coordinate asymmetric cell behaviors across development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据