4.8 Article

Phosphoproteomic responses of TORC1 target kinases reveal discrete and convergent mechanisms that orchestrate the quiescence program in yeast

期刊

CELL REPORTS
卷 37, 期 13, 页码 -

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CELL PRESS
DOI: 10.1016/j.celrep.2021.110149

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  1. Canton of Fribourg
  2. Swiss National Science Foundation [310030_166474/184671to, 310030_184781, 316030_177088]
  3. Novar-tis Foundation for Medical-Biological Research
  4. Swiss National Science Foundation (SNF) [316030_177088, 310030_184781] Funding Source: Swiss National Science Foundation (SNF)

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Eukaryotic TORC1 kinase controls growth by regulating anabolic and catabolic processes based on environmental cues. In yeast, TORC1 activates protein synthesis through Sch9 in response to abundant nutrients, while inhibition of TORC1 under nutrient limitation unlocks distally controlled kinases for coordinating the quiescence program.
The eukaryotic TORC1 kinase assimilates diverse environmental cues, including growth factors and nutrients, to control growth by tuning anabolic and catabolic processes. In yeast, TORC1 stimulates protein synthesis in response to abundant nutrients primarily through its proximal effector kinase Sch9. Conversely, TORC1 inhibition following nutrient limitation unlocks various distally controlled kinases (e.g., Atg1, Gcn2, Npr1, Rim15, Slt2/Mpk1, and Yak1), which cooperate through poorly defined circuits to orchestrate the quiescence program. To better define the signaling landscape of the latter kinases, we use in vivo quantitative phosphoproteomics. Through pinpointing known and uncharted Npr1, Rim15, Slt2/Mpk1, and Yak1 effectors, our study examines the architecture of the distally controlled TORC1 kinase network. Accordingly, this is built on a combination of discrete, convergent, and multilayered feedback regulatory mechanisms, which likely ensure homeostatic control of and/or robust responses by TORC1 and its effector kinases under fluctuating nutritional conditions.

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