期刊
CELL REPORTS
卷 37, 期 4, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109884
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资金
- French National Research Agency (ANRCE16-Myochronic)
- Fondation pour la Recherche Medicale (FRM) [FRM-EQP202003010192]
- CNRS
- Aix-Marseille-Universite
- Biotrail PhD fund
Pain, whether acute or persistent, is a serious medical problem worldwide. However, the management of pain remains unsatisfactory and new analgesic molecules are needed. The study shows that TAFA4 can reverse different forms of pain-induced mechanical hypersensitivity by restoring normal spinal neuron activity, highlighting its considerable potential as a treatment for injury-induced mechanical pain.
Pain, whether acute or persistent, is a serious medical problem worldwide. However, its management remains unsatisfactory, and new analgesic molecules are required. We show here that TAFA4 reverses inflammatory, postoperative, and spared nerve injury (SNI)-induced mechanical hypersensitivity in male and female mice. TAFA4 requires functional low-density lipoprotein receptor-related proteins (LRPs) because their inhibition by RAP (receptor-associated protein) dose-dependently abolishes its antihypersensitive actions. SNI selectively decreases A-type K+ current (IA) in spinal lamina II outer excitatory interneurons (L-IIo ExINs) and induces a concomitant increase in IA and decrease in hyperpolarization-activated current (Ih) in lamina II inner inhibitory interneurons (L-IIi InhINs). Remarkably, SNI-induced ion current alterations in both IN subtypes were rescued by TAFA4 in an LRP-dependent manner. We provide insights into the mechanism by which TAFA4 reverses injury-induced mechanical hypersensitivity by restoring normal spinal neuron activity and highlight the considerable potential of TAFA4 as a treatment for injury-induced mechanical pain.
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