期刊
CELL REPORTS
卷 37, 期 6, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109959
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资金
- SAMANA Kay MGHResearch Scholars award
- Ragon Institute of MGH, MIT and Harvard
- Massachusetts Consortium on Pathogen Readiness (MassCPR)
- NIH [3R37AI080289-11S1, R01AI146785, U19AI42790-01, U19AI135995-02, 1U01CA260476 - 01, CIVIC75N93019C00052, 3R01HD100022-02S2, R01HD100022-02]
- National Science Foundation [1745302]
- Gates Foundation Global Health Vaccine Accelerator Platform funding [OPP1146996, INV-001650]
- NHLBI [K08HL1469630-02, 3K08HL146963-02S1]
- March of Dimes [6-FY20-223]
- Musk Foundation
- Bill and Melinda Gates Foundation [INV-001650] Funding Source: Bill and Melinda Gates Foundation
Antibodies specific to SARS-CoV-2 are present in breastmilk, with IgA and IgM being the dominant types transferred from maternal serum. The antibodies in breastmilk show distinct functional characteristics compared to those in serum, indicating a selective transfer process for certain functional antibodies.
Antibody transfer via breastmilk represents an evolutionary strategy to boost immunity in early life. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies have been observed in the breastmilk, the functional quality of these antibodies remains unclear. Here, we apply systems serology to characterize SARS-CoV-2-specific antibodies in maternal serum and breastmilk to compare the functional characteristics of antibodies in these fluids. Distinct SARS-CoV-2-specific antibody responses are observed in the serum and breastmilk of lactating individuals previously infected with SARS-CoV-2, with a more dominant transfer of immunoglobulin A (IgA) and IgM into breastmilk. Although IgGs are present in breastmilk, they are functionally attenuated. We observe preferential transfer of antibodies capable of eliciting neutrophil phagocytosis and neutralization compared to other functions, pointing to selective transfer of certain functional antibodies to breastmilk. These data highlight the preferential transfer of SARS-CoV-2-specific IgA and IgM to breastmilk, accompanied by select IgG subpopulations, positioned to create a non-pathologic but protective barrier against coronavirus disease 2019 (COVID-19).
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