期刊
CELL REPORTS
卷 37, 期 12, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.110134
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资金
- European Research Council (ERC) [639272]
- Research Council of Norway [231495, 276047, 274306]
- EEA grant [RO-NO-2019-0504]
- European Research Council (ERC) [639272] Funding Source: European Research Council (ERC)
The study reveals that AHV cells are widely distributed in the brain, including in areas related to motor, somatosensory, visual, and posterior parietal cortex. The tuning properties of AHV cells are influenced by vestibular input and vision, with varying contributions at different speeds.
Neurons that signal the angular velocity of head movements (AHV cells) are important for processing visual and spatial information. However, it has been challenging to isolate the sensory modality that drives them and to map their cortical distribution. To address this, we develop a method that enables rotating awake, head fixed mice under a two-photon microscope in a visual environment. Starting in layer 2/3 of the retrosplenial cortex, a key area for vision and navigation, we find that 10% of neurons report angular head velocity (AHV). Their tuning properties depend on vestibular input with a smaller contribution of vision at lower speeds. Mapping the spatial extent, we find AHV cells in all cortical areas that we explored, including motor, somatosensory, visual, and posterior parietal cortex. Notably, the vestibular and visual contributions to AHV are area dependent. Thus, many cortical circuits have access to AHV, enabling a diverse integration with sensorimotor and cognitive information.
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