4.8 Article

Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Increased thin-spine density in frontal cortex pyramidal neurons in a genetic rat model of schizophrenia-relevant features

A. Sanchez-Gonzalez et al.

Summary: Altered cellular mechanisms in brain wiring during adolescence may lead to cognitive disturbances in neurodevelopmental disorders. In a genetic animal model of schizophrenia-relevant behavior, the RHA-I rat strain showed increased dendritic spine density with a higher proportion of immature thin spines. Additionally, there was a significantly higher number of GFAP-positive astrocytes in the FC of the RHA-I strain, indicating a more immature FC structure.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2021)

Article Multidisciplinary Sciences

A non-hallucinogenic psychedelic analogue with therapeutic potential

Lindsay P. Cameron et al.

Summary: The study identifies key structural elements of the potential therapeutic pharmacophore of ibogaine and designs tabernanthalog, a safer, non-hallucinogenic analogue of ibogaine. Tabernanthalog is found to promote neural plasticity, reduce addiction-related behavior, and produce antidepressant effects in rodents. Through careful chemical design, it is possible to modify psychedelic compounds to produce safer, non-hallucinogenic variants with therapeutic potential.

NATURE (2021)

Review Neurosciences

A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics

Neil K. Savalia et al.

Summary: Studies have shown that serotonergic psychedelics like psilocybin and ketamine may relieve depression by promoting neural plasticity. Despite targeting distinct molecular receptors in the brain, the behavioral and neural effects of these compounds are similar, possibly by enhancing and suppressing membrane excitability at dendrites.

TRENDS IN NEUROSCIENCES (2021)

Article Multidisciplinary Sciences

Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing

L. S. Kaertner et al.

Summary: The study found that psychedelic microdosing may enhance psychological well-being, emotional stability, and reduce anxiety and depressive symptoms, but positive expectancy also plays a significant role in predicting positive outcomes.

SCIENTIFIC REPORTS (2021)

Article Medicine, General & Internal

Trial of Psilocybin versus Escitalopram for Depression

Robin Carhart-Harris et al.

Summary: The study compared the efficacy of psilocybin and escitalopram in treating patients with major depressive disorder. While there was no significant difference in antidepressant effects between the two drugs at week 6, secondary outcomes generally favored psilocybin over escitalopram, though these results were not adjusted for multiple comparisons. Larger and longer trials are needed to further compare psilocybin with established antidepressants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice

Natalie Hesselgrave et al.

Summary: Psilocybin has shown promising rapid and persistent antidepressant effects in mice, possibly through enhancing excitatory synapses in the hippocampus, independent of 5-HT2A receptor activation. Further research is needed to explore the potential combination of psychedelic compounds and 5-HT2AR antagonists for clinical utility in human depression.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Psychiatry

Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder A Randomized Clinical Trial

Alan K. Davis et al.

Summary: The study showed that psilocybin therapy with psychological support is effective in treating MDD, building on previous findings in patients with cancer and depression, as well as in a nonrandomized study in patients with treatment-resistant depression.

JAMA PSYCHIATRY (2021)

Article Neurosciences

Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

Ling-Xiao Shao et al.

Summary: The study showed that psilocybin can induce rapid and lasting synaptic rewiring in the cortex, increasing spine size and density. This structural change may have potential implications for long-term integration of experiences and lasting beneficial actions.

NEURON (2021)

Article Chemistry, Medicinal

The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects

David E. Olson

Summary: Psychedelics have shown promise for treating neuropsychiatric disorders due to their ability to promote neural plasticity and produce rapid and sustained therapeutic effects, but evidence suggests that the subjective effects induced by these drugs may not be necessary for long-lasting changes in mood and behavior. Understanding the role of subjective effects in the therapeutic mechanisms of psychedelics will have important implications for basic neuroscience and patient access to future medicines developed from psychedelic research.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

Article Chemistry, Medicinal

The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects

David B. Yaden et al.

Summary: The subjective effects of psychedelics are crucial for their lasting benefits, accounting for the majority of their therapeutic outcomes.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

Review Neurosciences

Neurobiological functions of transcriptional enhancers

Alex S. Nord et al.

NATURE NEUROSCIENCE (2020)

Article Multidisciplinary Sciences

An atlas of dynamic chromatin landscapes in mouse fetal development

David U. Gorkin et al.

NATURE (2020)

Article Psychology, Clinical

Depression and Suicidal Behavior in Young Adult Men and Women With ADHD: Evidence From Claims Data

Dara E. Babinski et al.

JOURNAL OF CLINICAL PSYCHIATRY (2020)

Article Multidisciplinary Sciences

(2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions

Panos Zanos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Neurosciences

The critical importance of basic animal research for neuropsychiatric disorders

Tracy L. Bale et al.

NEUROPSYCHOPHARMACOLOGY (2019)

Article Biochemical Research Methods

MOWChIP-seq for low-input and multiplexed profiling of genome-wide histone modifications

Bohan Zhu et al.

NATURE PROTOCOLS (2019)

Article Multidisciplinary Sciences

Fully automated head-twitch detection system for the study of 5-HT2A receptor pharmacology in vivo

Mario de la Fuente Revenga et al.

SCIENTIFIC REPORTS (2019)

Review Behavioral Sciences

Chromatin regulation in complex brain disorders

Ryan M. Bastle et al.

CURRENT OPINION IN BEHAVIORAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

Effects of N,N-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression

Lindsay P. Cameron et al.

ACS CHEMICAL NEUROSCIENCE (2018)

Article Cell Biology

Psychedelics Promote Structural and Functional Neural Plasticity

Calvin Ly et al.

CELL REPORTS (2018)

Article Neurosciences

Role of mGlu2 in the 5-HT2A receptor-dependent antipsychotic activity of clozapine in mice

Kelsey S. Hideshima et al.

PSYCHOPHARMACOLOGY (2018)

Article Genetics & Heredity

Characterisation of CASPR2 deficiency disorder - a syndrome involving autism, epilepsy and language impairment

Pedro Rodenas-Cuadrado et al.

BMC MEDICAL GENETICS (2016)

Review Neurosciences

Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression

Anthony A. Grace

NATURE REVIEWS NEUROSCIENCE (2016)

Review Pharmacology & Pharmacy

Psychedelics

David E. Nichols

PHARMACOLOGICAL REVIEWS (2016)

Article Physiology

Serotonin 5-HT2 receptor activation prevents allergic asthma in a mouse model

Felix Nau et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2015)

Article Biochemical Research Methods

ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization

Guangchuang Yu et al.

BIOINFORMATICS (2015)

Article Neurosciences

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

Yasmin Schmid et al.

BIOLOGICAL PSYCHIATRY (2015)

Article Biochemical Research Methods

HISAT: a fast spliced aligner with low memory requirements

Daehwan Kim et al.

NATURE METHODS (2015)

Article Biochemical Research Methods

A microfluidic device for epigenomic profiling using 100 cells

Zhenning Cao et al.

NATURE METHODS (2015)

Review Neurosciences

Neuronal circuits for fear and anxiety

Philip Tovote et al.

NATURE REVIEWS NEUROSCIENCE (2015)

Article Biochemical Research Methods

Full-length RNA-seq from single cells using Smart-seq2

Simone Picelli et al.

NATURE PROTOCOLS (2014)

Article Neurosciences

Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia

David A. Martin et al.

NEUROPHARMACOLOGY (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Animal Models of Serotonergic Psychedelics

James B. Hanks et al.

ACS CHEMICAL NEUROSCIENCE (2013)

Article Biochemical Research Methods

Smart-seq2 for sensitive full-length transcriptome profiling in single cells

Simone Picelli et al.

NATURE METHODS (2013)

Review Neurosciences

Histone acetylation: molecular mnemonics on the chromatin

Johannes Graeff et al.

NATURE REVIEWS NEUROSCIENCE (2013)

Review Neurosciences

Molecular mechanisms of dendrite stability

Anthony J. Koleske

NATURE REVIEWS NEUROSCIENCE (2013)

Article Multidisciplinary Sciences

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

Caryn S. Ross-Innes et al.

NATURE (2012)

Article Biochemical Research Methods

Fast gapped-read alignment with Bowtie 2

Ben Langmead et al.

NATURE METHODS (2012)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Article Multidisciplinary Sciences

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

Matthew T. Maurano et al.

SCIENCE (2012)

Review Multidisciplinary Sciences

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

Ronald S. Duman et al.

SCIENCE (2012)

Review Biochemistry & Molecular Biology

What does CNTNAP2 reveal about autism spectrum disorder?

Olga Penagarikano et al.

TRENDS IN MOLECULAR MEDICINE (2012)

Article Biochemical Research Methods

BEDTools: a flexible suite of utilities for comparing genomic features

Aaron R. Quinlan et al.

BIOINFORMATICS (2010)

Article Neurosciences

Axon Growth and Guidance Genes Identify Nascent, Immature, and Mature Olfactory Sensory Neurons

Jeremy C. McIntyre et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2010)

Review Biochemistry & Molecular Biology

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

Amar J. Majmundar et al.

MOLECULAR CELL (2010)

Article Multidisciplinary Sciences

Psychedelics and the Human Receptorome

Thomas S. Ray

PLOS ONE (2010)

Article Multidisciplinary Sciences

Histone H3K27ac separates active from poised enhancers and predicts developmental state

Menno P. Creyghton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemical Research Methods

The Sequence Alignment/Map format and SAMtools

Heng Li et al.

BIOINFORMATICS (2009)

Article Multidisciplinary Sciences

Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling

Kelly A. Jones et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Editorial Material Health Policy & Services

The STAR*D Trial: Revealing the Need for Better Treatments

Thomas R. Insel et al.

PSYCHIATRIC SERVICES (2009)

Article Biochemical Research Methods

WGCNA: an R package for weighted correlation network analysis

Peter Langfelder et al.

BMC BIOINFORMATICS (2008)

Article Multidisciplinary Sciences

The molecular neurobiology of depression

Vaishnav Krishnan et al.

NATURE (2008)

Review Neurosciences

Pyramidal neurons: dendritic structure and synaptic integration

Nelson Spruston

NATURE REVIEWS NEUROSCIENCE (2008)

Article Biotechnology & Applied Microbiology

Model-based Analysis of ChIP-Seq (MACS)

Yong Zhang et al.

GENOME BIOLOGY (2008)

Article Biochemistry & Molecular Biology

CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy

J. I. Friedman et al.

MOLECULAR PSYCHIATRY (2008)

Article Biochemistry & Molecular Biology

A general framework for weighted gene co-expression network analysis

Bin Zhang et al.

STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY (2005)

Article Medicine, General & Internal

The epidemiology of major depressive disorder - Results from the National Comorbidity Survey Replication (NCS-R).

RC Kessler et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)

Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

Article Clinical Neurology

Psychostimulants and epilepsy

PG Zagnoni et al.

EPILEPSIA (2002)