期刊
CELL REPORTS
卷 37, 期 3, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2021.109854
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资金
- National Key Research and Development Program of China [2017YFA0503900]
- National Natural Science Foundation of China [81572711, 81672859]
The study reveals that RNF8 is overexpressed in lung cancer and promotes cancer cell proliferation and resistance to chemotherapy. Therefore, RNF8 could be a very promising target in precision medicine for lung cancer.
Despite the tremendous success of targeted and conventional therapies for lung cancer, therapeutic resistance is a common and major clinical challenge. RNF8 is a ubiquitin E3 ligase that plays essential roles in the DNA damage response; however, its role in the pathogenesis of lung cancer is unclear. Here, we report that RNF8 is overexpressed in lung cancer and positively correlates with the expression of p-Akt and poor survival of patients with non-small-cell lung cancer. In addition, we identify RNF8 as the E3 ligase for regulating the activation of Akt by K63-linked ubiquitination under physiological and genotoxic conditions, which leads to lung cancer cell proliferation and resistance to chemotherapy. Together, our study suggests that RNF8 could be a very promising target in precision medicine for lung cancer.
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