4.7 Article

Ontogeny of RORγt+ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis

期刊

CELL AND BIOSCIENCE
卷 12, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s13578-021-00739-6

关键词

Neonate; Necrotizing enterocolitis; Intestinal immune; ROR gamma t

资金

  1. National Key Research and Development Program of China [SQ2018YFA090045-01]
  2. National Natural Science Foundation of China [81871194, 81771739, 82071852]
  3. Program for Professor of Special Appointments (Eastern Scholar) at Shanghai Institutions of Higher Learning
  4. Top Young Talent Program of Shanghai
  5. Technology Committee of Shanghai Municipality [18ZR14311300, 18JC1414100, 20410713800]

向作者/读者索取更多资源

The high proportion of ROR gamma t (+) cells in newborn mice may directly contribute to the development of NEC.
Background: Neonates possess an immature and plastic immune system, which is a major cause of some diseases in newborns. Necrotizing enterocolitis (NEC) is a severe and devastating intestinal disease that typically affects premature infants. However, the development of intestinal immune cells in neonates and their roles in the pathological process of NEC have not been elucidated. Results: We examined the ontogeny of intestinal lamina propria lymphocytes in the early life of mice and found a high percentage of ROR gamma t(+) cells (containing inflammatory Th17 and ILC3 populations) during the first week of life. Importantly, the proportion of ROR gamma t(+) cells of intestinal lamina propria further increased in both NEC mice and patients tissue than the control. Furthermore, the application of GSK805, a specific antagonist of ROR gamma t, inhibited IL-17A release and ameliorated NEC severity. Conclusions: Our data reveal the high proportion of ROR gamma t(+) cells in newborn mice may directly contribute to the development of NEC.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据