Impaired neutralizing antibody response to COVID-19 mRNA vaccines in cancer patients

Article Gastroenterology & Hepatology

Low immunogenicity to SARS-CoV-2 vaccination among liver transplant recipients

Liane Rabinowich et al.

Summary: Liver transplant recipients showed significantly lower immunological response to the Pfizer-BioNTech SARS-CoV-2 mRNA-based vaccine, with less than half developing sufficient levels of antibodies and lower average antibody levels compared to healthy controls. Predictors for non-response included older age, renal function and immunosuppressive medications.

JOURNAL OF HEPATOLOGY (2021)

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Letter Oncology

Antibody response to SARS-CoV-2 vaccines in patients with hematologic malignancies

Lee M. Greenberger et al.

CANCER CELL (2021)

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Article Multidisciplinary Sciences

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Dami A. Collier et al.

Summary: Elderly individuals, especially those above eighty, show lower immune responses and neutralization abilities against variants of concern after the first vaccine dose, but this improves after the second dose. They have higher frequencies of spike-specific memory B cells but reduced somatic hypermutation of class-switched cells. Production of interferon-gamma and interleukin-2 by SARS-CoV-2 spike-specific T cells is lower in older participants, predominantly by CD4 T cells.

NATURE (2021)

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Letter Medicine, General & Internal

Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce

Jocelyn Keehner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Oncology

Implications of mRNA-based SARS-CoV-2 vaccination for cancer patients

Emanuela Romano et al.

Summary: The ongoing COVID-19 pandemic has affected millions worldwide, including vulnerable populations such as cancer patients. Currently approved mRNA vaccines appear suitable for cancer patients, but challenges exist in the vaccination process.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Oncology