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Article
Health Policy & Services
Bruce Rosen et al.
Summary: Israel achieved high vaccination coverage and overcame barriers to vaccine uptake through a combination of efforts targeting the general population and specific subgroups. The country's vaccination campaign faced challenges such as hesitancy, access issues, and confusion about vaccine effectiveness, which were addressed through messaging, incentives, and adaptations to the delivery system. The strategies used by Israel to improve vaccine uptake may be relevant to other countries facing similar challenges in vaccination campaigns.
ISRAEL JOURNAL OF HEALTH POLICY RESEARCH
(2021)
Editorial Material
Infectious Diseases
Dafna Yahav et al.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Multidisciplinary Sciences
Christian Gaebler et al.
Summary: After infection with SARS-CoV-2, antibody levels against the spike protein decrease significantly, but the number of memory B cells remain unchanged, indicating an evolving humoral response at 6.2 months after infection.
Article
Biochemistry & Molecular Biology
Jerome H. Kim et al.
Summary: Following the announcement of COVID-19 vaccine efficacy in clinical trials, a comprehensive strategy is needed for global vaccination, including manufacturing, support, supply coordination, equitable distribution, and logistics. Additionally, addressing scientific questions to improve vaccine efficacy is crucial for ending the pandemic effectively and efficiently.
Article
Medicine, General & Internal
S. F. Lumley et al.
Summary: In a longitudinal study of seropositive and seronegative health care workers undergoing asymptomatic and symptomatic SARS-CoV-2 testing, the presence of anti-spike or anti-nucleocapsid IgG antibodies was associated with a substantially reduced risk of SARS-CoV-2 reinfection in the ensuing 6 months.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Physiology
Varnica Bajaj et al.
Summary: The novel coronavirus has greatly impacted the world with over 72 million cases and 1.6 million deaths, mostly affecting the elderly population. Aging leads to changes in the immune system, making elderly individuals more susceptible to infections and less responsive to vaccines. Understanding age-related immune system changes is crucial for managing infectious diseases like COVID-19.
FRONTIERS IN PHYSIOLOGY
(2021)
News Item
Multidisciplinary Sciences
Smriti Mallapaty
Summary: This country is the first to witness the direct impact of vaccines in such a large group of people.
Article
Multidisciplinary Sciences
Pengfei Wang et al.
Summary: The COVID-19 pandemic has had global repercussions, with promising vaccines and monoclonal antibody therapies. However, newly detected variants of SARS-CoV-2 present challenges to these treatment options.
Article
Multidisciplinary Sciences
Adam K. Wheatley et al.
Summary: The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Antibody, B cell, and T cell responses decline over the first 4 months post-infection, while S-specific IgG(+) memory B cells consistently accumulate. The study suggests that natural infection may only provide transient protection at a population level, highlighting the need for more immunogenic and durable vaccines.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Megan M. Sheehan et al.
Summary: The study found that prior infection in patients with COVID-19 provided a high level of protection against reinfection and symptomatic disease, with this protection increasing over time. This suggests that viral shedding or ongoing immune response may persist beyond 90 days, and may not necessarily represent true reinfection.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
David S. Khoury et al.
Summary: The level of neutralizing antibodies is closely related to immune protection against COVID-19, playing a crucial role in protecting against detected infection and severe infection. Studies have shown that neutralizing titers will decline over time after vaccination, leading to decreased protection against SARS-CoV-2 infection.
Article
Cardiac & Cardiovascular Systems
Rene Schramm et al.
Summary: Ninety percent of cardiothoracic transplant patients showed no detectable immune response three weeks after receiving two doses of the BNT162b2 vaccine, in sharp contrast to the robust immune response seen in the control group.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Letter
Immunology
Brian J. Boyarsky et al.
Editorial Material
Immunology
Aviad Raz et al.
Article
Oncology
H. Parry et al.
Summary: CLL patients have lower antibody responses after both first and second Covid-19 vaccine doses compared to healthy donors. Patients currently treated with BTK inhibitors or with IgA deficiency are more likely to fail to generate an antibody response after the second vaccine. This study supports the need for optimizing vaccination strategies in CLL patients, potentially including the use of booster vaccines.
BLOOD CANCER JOURNAL
(2021)
Article
Health Policy & Services
Bruce Rosen et al.
Summary: Israel has stood out for its rapid and effective COVID-19 vaccine rollout, with factors contributing to its success falling into categories of long-standing characteristics, health-system specific features, and recent efforts specific to the vaccination campaign. The synergy created among these facilitating factors has been crucial in Israel's success, distinguishing it from other high-income countries like the US, the UK, and Canada that have faced slower vaccine distribution due to lacking some of these factors.
ISRAEL JOURNAL OF HEALTH POLICY RESEARCH
(2021)
Editorial Material
Medicine, General & Internal
Manish M. Patel et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Public, Environmental & Occupational Health
Sheena G. Sullivan et al.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2016)
Article
Health Policy & Services
Rola Hamood et al.
ISRAEL JOURNAL OF HEALTH POLICY RESEARCH
(2016)
Article
Immunology
S Crotty et al.
JOURNAL OF IMMUNOLOGY
(2003)
