期刊
BMJ-BRITISH MEDICAL JOURNAL
卷 375, 期 -, 页码 -出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/bmj-2021-067873
关键词
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资金
- Leumit Health Services
- Intramural Research Program, National Institutes of Health, National Cancer Institute, Center for Cancer Research
In this study, it was found that the risk of COVID-19 infection gradually increased in adults who received their second dose of the BNT162b2 mRNA vaccine after at least 90 days, based on electronic health records.
OBJECTIVES To determine whether time elapsed since the second injection of the Pfizer-BioNTech BNT162b2 mRNA vaccine was significantly associated with the risk of covid-19 infection after vaccination in people who received two vaccine injections. DESIGN Test negative design study. SETTING Electronic health records of a large state mandated healthcare organisation, Israel. PARTICIPANTS Adults aged >= 18 years who had received a reverse transcription polymerase chain reaction (RT-PCR) test between 15 May 2021 and 17 September 2021, at least three weeks after their second vaccine injection, had not received a third vaccine injection, and had no history of covid-19 infection. MAIN OUTCOME MEASURES Positive result for the RT-PCR test. Individuals who tested positive for SARS-CoV-2 and controls were matched for week of testing, age category, and demographic group (ultra-orthodox Jews, individuals of Arab ancestry, and the general population). Conditional logistic regression was adjusted for age, sex, socioeconomic status, and comorbid conditions. RESULTS 83 057 adults received an RT-PCR test for SARS-CoV-2 during the study period and 9.6% had a positive result. Time elapsed since the vaccine injection was significantly longer in individuals who tested positive (P<0.001). Adjusted odds ratio for infection at time intervals >90 days since vaccination were significantly increased compared with the reference of <90 days: 2.37 (95% confidence interval 1.67 to 3.36) for 90119 days, 2.66 (1.94 to 3.66) for 120-149 days, 2.82 (2.07 to 3.84) for 150-179 days, and 2.82 (2.07 to 3.85) for >= 180 days (P<0.001 for each 30 day interval). CONCLUSIONS In this large population of adults tested for SARSCoV-2 by RT-PCR after two doses of mRNA BNT162b2 vaccine, a gradual increase in the risk of infection was seen for individuals who received their second vaccine dose after at least 90 days.
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