期刊
BMJ-BRITISH MEDICAL JOURNAL
卷 375, 期 -, 页码 -出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/bmj.n2400
关键词
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资金
- Task 54, Defense Research Development Canada, Department of National Defense, Ottawa, Canada
- St Michael's Hospital Foundation, Toronto, Canada
- St Joseph's Health Centre Foundation, Toronto, Canada
- 2020 TD Community Health Solutions Fund -COVID-19 research grant
- Michael Garron Hospital, Toronto, Canada
- The Ottawa Hospital Foundation COVID-19 Emergency Response Fund, Ottawa, Canada
- International Network of Venous Thromboembolism Clinical Research Networks (INVENT) Kickstarter Award
- Science Foundation Ireland, Enterprise Ireland, IDA Ireland COVID-19 Rapid Response Funding [20/COV/0157]
- SEAMO (South-eastern Ontario Academic Medical Organization) COVID-19 Innovation Fund
- National Institute of General Medical Sciences, National Institutes of Health [P20 GM135007]
- University of Vermont Medical Center Fund Grant
- College of Medicine Research Center
- King Saud University, Riyadh, Saudi Arabia
This study aimed to evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. The results of the study may help guide the treatment options for similar patients in the future.
OBJECTIVE To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. DESIGN Randomised controlled, adaptive, open label clinical trial. SETTING 28 hospitals in Brazil, Canada, Ireland, Saudi Arabia, United Arab Emirates, and US. PARTICIPANTS 465 adults admitted to hospital wards with covid-19 and with increased D-dimer levels were recruited between 29 May 2020 and 12 April 2021 and were randomly assigned to therapeutic dose heparin (n=228) or prophylactic dose heparin (n=237). INTERVENTIONS Therapeutic dose or prophylactic dose heparin (low molecular weight or unfractionated heparin), to be continued until hospital discharge, day 28, or death.
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