4.6 Article

Implementation, efficacy and cost effectiveness of the unified protocol in a blended format for the transdiagnostic treatment of emotional disorders: a study protocol for a multicentre, randomised, superiority controlled trial in the Spanish National Health System

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On the efficacy of the unified protocol for transdiagnostic treatment of emotional disorders: A systematic review and meta-analysis

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Summary: The meta-analysis suggests that the Transdiagnostic Unified Protocol (UP) has significant effects on reducing symptoms of depression and anxiety, with a large effect size observed from pre-treatment to 3-6 months follow-up. UP treatment does not differ across anxiety and depression self-report measures and outperforms control conditions in treating negative affective syndromes. Meta-regression confirms the moderate effects of therapist experience, sample characteristics, and UP-protocol adaptations.

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