4.6 Article

Predictive model and risk analysis for diabetic retinopathy using machine learning: a retrospective cohort study in China

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Review Ophthalmology

Retinal capillary basement membrane thickening: Role in the pathogenesis of diabetic retinopathy

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Summary: Vascular basement membrane (BM) thickening is recognized as a prominent histological lesion in diabetic microangiopathy and early structural abnormality in diabetic retinopathy (DR). Excess accumulation of BM components and hyperglycemia may contribute to BM thickening, resulting in cell death and vascular leakage in the diabetic retina. Preventing BM thickening through gene regulatory approaches is being explored as a potential therapeutic strategy for alleviating characteristic lesions associated with DR.

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