4.5 Article

Risk of coronary heart disease in patients with periodontitis among the middled-aged and elderly in China: a cohort study

期刊

BMC ORAL HEALTH
卷 21, 期 1, 页码 -

出版社

BMC
DOI: 10.1186/s12903-021-01951-z

关键词

Periodontitis; Coronary heart disease; Oral health; Cohort study

资金

  1. Chinese Research Unit of Tooth Development and Regeneration, CAMSI Innovation Fund for Medical Sciences, [2019-12M-5-031]
  2. National Natural Science Foundation of China [91649124]
  3. Beijing Municipal Science & Technology Commission [Z181100001718208]
  4. Beijing Municipal Education Commission [119207020201]
  5. Beijing Hospitals Authority of Hospitals' Mission Plan [SML20151401]
  6. Beijing Municipality Government grants [Z181100001718208, PXM2018_014226_000021, PXM2018_193312_000006_0028S643_ FCG, PXM2019_014226_000011, PXM2020_014226_000005]

向作者/读者索取更多资源

Periodontitis was weakly associated with an increased risk of CHD among middle-aged and elderly in China, with most of the association explained by age, sex, history of diabetes, history of hypertension, uric acid, and education. Further studies are required to identify more mediators and elucidate the mechanisms of how periodontitis increases the risk of CHD.
Background Convincing evidence of the periodontitis as a risk factor for coronary heart disease (CHD) is lacking due to shared risk factors, and no cohort study has investigated the association between CHD and periodontitis in Chinese populations. Methods This study used a prospective cohort study design. The analysis included 4591 participants aged 40 years and older (3146 men and 1445 women). The association between CHD and periodontitis was estimated using relative risk (RR) calculated using modified Poisson regression. Multiple mediation analysis was used to differentiate the relative effects (RE) from different risk factors on the effect of periodontitis on CHD. Results In the analysis using the imputed dataset and fully adjusted model, participants with periodontitis at baseline had 37% increased risk of CHD overall compared to those without periodontitis at baseline (RR 1.37; 95% CI 0.96-1.95). Most of the association can be explained by age, sex, history of diabetes, history of hypertension, uric acid and education (RE 0.76; 95% CI 0.41-1.02). Conclusion Periodontitis was weakly associated with an increased risk of CHD among the middled-aged and elderly in China. Further studies are required to identify more mediators and elucidate the mechanisms of how periodontitis increases the risk of CHD.

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