相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Potent Tau Aggregation Inhibitor D-Peptides Selected against Tau-Repeat 2 Using Mirror Image Phage Display
Marwa Malhis et al.
CHEMBIOCHEM (2021)
Microglial activation and tau propagate jointly across Braak stages
Tharick A. Pascoal et al.
NATURE MEDICINE (2021)
FDA approval for Biogen's aducanumab sparks Alzheimer disease firestorm
Asher Mullard
NATURE REVIEWS DRUG DISCOVERY (2021)
Aducanumab for Alzheimer's disease?
Sebastian Walsh et al.
BMJ-BRITISH MEDICAL JOURNAL (2021)
Failure to demonstrate efficacy of aducanumab: An analysis of the EMERGE and ENGAGE trials as reported by Biogen, December 2019
David S. Knopman et al.
ALZHEIMERS & DEMENTIA (2021)
Will We Have a Drug for Alzheimer's Disease by 2030? The View From Pharma
Simon Lovestone et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2020)
Modulating disease-relevant tau oligomeric strains by small molecules
Filippa Lo Cascio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Selection of a D-Enantiomeric Peptide Specifically Binding to PHF6 for Inhibiting Tau Aggregation in Transgenic Mice
Xiancheng Zhang et al.
ACS CHEMICAL NEUROSCIENCE (2020)
Novel antibody against low-n oligomers of tau protein promotes clearance of tau in cells via lysosomes
Ram Reddy Chandupatla et al.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2020)
Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment
Ghulam Jeelani Pir et al.
MOLECULAR NEUROBIOLOGY (2019)
A walk through tau therapeutic strategies
Santosh Jadhav et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)
Screening of a neuronal cell model of tau pathology for therapeutic compounds
Marcus Pickhardt et al.
NEUROBIOLOGY OF AGING (2019)
Do We Need Anti-Prion Compounds to Treat Alzheimer's Disease?
Dieter Willbold et al.
MOLECULES (2019)
Anti-Tau Trials for Alzheimer's Disease: A Report from the EU/US/CTAD Task Force
J. Cummings et al.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE (2019)
Structure-based inhibitors of tau aggregation
P. M. Seidler et al.
NATURE CHEMISTRY (2018)
Anti-Amyloid-β Monoclonal Antibodies for Alzheimer's Disease: Pitfalls and Promise
Christopher H. van Dyck
BIOLOGICAL PSYCHIATRY (2018)
Why do trials for Alzheimer's disease drugs keep failing? A discontinued drug perspective for 2010-2015
Dev Mehta et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2017)
Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer's Disease
Janine Kutzsche et al.
MOLECULES (2017)
Time course of Tau toxicity and pharmacologic prevention in a cell model of Tauopathy
Marcus Pickhardt et al.
NEUROBIOLOGY OF AGING (2017)
Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability
Senthilvelrajan Kaniyappan et al.
ALZHEIMERS & DEMENTIA (2017)
Amyloid beta: structure, biology and structure-based therapeutic development
Guo-fang Chen et al.
ACTA PHARMACOLOGICA SINICA (2017)
Pharmacokinetic Properties of a Novel D-Peptide Developed to be Therapeutically Active Against Toxic β-Amyloid Oligomers
Leonie H. E. Leithold et al.
PHARMACEUTICAL RESEARCH (2016)
Selective Inhibition of Aggregation and Toxicity of a Tau-Derived Peptide using Its Glycosylated Analogues
Moran Frenkel-Pinter et al.
CHEMISTRY-A EUROPEAN JOURNAL (2016)
Selection and Characterization of Tau Binding D-Enantiomeric Peptides with Potential for Therapy of Alzheimer Disease
Christina Dammers et al.
PLOS ONE (2016)
Does multilingualism affect the incidence of Alzheimer's disease?: A worldwide analysis by country
Raymond M. Klein et al.
SSM-POPULATION HEALTH (2016)
Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein
Michel Goedert
SCIENCE (2015)
Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca++ dysregulation
Jochen Martin Decker et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau
Katja Hochgraefe et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
Tau-aggregation inhibitor therapy for Alzheimer's disease
Claude M. Wischik et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Capping Amyloid β-Sheets of the Tau-Amyloid Structure VQIVYK with Hexapeptides Designed To Arrest Growth. An ONIOM and Density Functional Theory Study
Joshua A. Plumley et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2014)
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease
Cristian A. Lasagna-Reeves et al.
FASEB JOURNAL (2012)
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimers diseases
Giovanni Coppola et al.
HUMAN MOLECULAR GENETICS (2012)
Strategies, Development, and Pitfalls of Therapeutic Options for Alzheimer's Disease
Christopher Haas
JOURNAL OF ALZHEIMERS DISEASE (2012)
Tau Oligomers Impair Artificial Membrane Integrity and Cellular Viability
Katharina Flach et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Macrocyclic β-Sheet Peptides That Inhibit the Aggregation of a Tau-Protein-Derived Hexapeptide
Jing Zheng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
Stuart A. Sievers et al.
NATURE (2011)
Oral Treatment with the D-Enantiomeric Peptide D3 Improves the Pathology and Behavior of Alzheimer's Disease Transgenic Mice
Susanne Aileen Funke et al.
ACS CHEMICAL NEUROSCIENCE (2010)
Preparation and Characterization of Neurotoxic Tau Oligomers
Cristian A. Lasagna-Reeves et al.
BIOCHEMISTRY (2010)
SAROTUP: Scanner and Reporter of Target-Unrelated Peptides
Jian Huang et al.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)
Tau protein and tau aggregation inhibitors
Bruno Bulic et al.
NEUROPHARMACOLOGY (2010)
Conformational Changes Specific for Pseudophosphorylation at Serine 262 Selectively Impair Binding of Tau to Microtubules
Daniela Fischer et al.
BIOCHEMISTRY (2009)
Identification of Aminothienopyridazine Inhibitors of Tau Assembly by Quantitative High-Throughput Screening
Alex Crowe et al.
BIOCHEMISTRY (2009)
Reduction of Alzheimer's Disease Amyloid Plaque Load in Transgenic Mice by D3, a D-Enantiomeric Peptide Identified by Mirror Image Phage Display
Thomas van Groen et al.
CHEMMEDCHEM (2008)
The β-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy
Katrin Eckermann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
TAT transduction: the molecular mechanism and therapeutic prospects
Jacob M. Gump et al.
TRENDS IN MOLECULAR MEDICINE (2007)
Atomic structures of amyloid cross-β spines reveal varied steric zippers
Michael R. Sawaya et al.
NATURE (2007)
Granular tau oligomers as intermediates of tau filaments
Sumihiro Maeda et al.
BIOCHEMISTRY (2007)
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
Carlo Ballatore et al.
NATURE REVIEWS NEUROSCIENCE (2007)
Tau suppression in a neurodegenerative mouse model improves memory function
K SantaCruz et al.
SCIENCE (2005)
Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
S Taniguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Membrane-permeable arginine-rich peptides and the translocation mechanisms
S Futaki
ADVANCED DRUG DELIVERY REVIEWS (2005)
Template-assisted filament growth by parallel stacking of tau
M Margittai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The formation of straight and twisted filaments from short tau peptides
WJ Goux et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
UCSF chimera - A visualization system for exploratory research and analysis
EF Pettersen et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
Stereoselective interactions of peptide inhibitors with the β-amyloid peptide
RJ Chalifour et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Emerging beta-amyloid therapies for the treatment of Alzheimer's disease
KA Conway et al.
CURRENT PHARMACEUTICAL DESIGN (2003)
Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local β-structure
M von Bergen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias
S Barghorn et al.
BIOCHEMISTRY (2000)
Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif (306VQIVYK311) forming β structure
M von Bergen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)