期刊
ALZHEIMERS RESEARCH & THERAPY
卷 14, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13195-021-00952-y
关键词
Sleepiness; Hypnotic use; Insomnia complaints; Dementia; Alzheimer; Elderly; Cohort studies; Epidemiology
资金
- The Fondation pour la Recherche Medicale
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante
- MGEN
- Institut de la Longevite
- Agence Francaise de Securite Sanitaire des Produits de Sante
- Regional Governments of Aquitaine
- Bourgogne and LanguedocRoussillon
- Fondation de France
- Ministry of Research-Inserm Programme Cohorts and collection of biological material.
- Eisai
- Agence Nationale de la Recherche (ANR) [07 LVIE 004, 06-PNRA-005]
- Fonds de cooperation scientifique Alzheimer [FCS 2009-2012]
Sleep disturbances are associated with dementia in the elderly, with excessive daytime sleepiness and hypnotics increasing the risk of dementia, while insomnia complaints and sleep quality are unrelated. Further research is needed to determine if managing sleep disturbances can prevent dementia.
Background Sleep disturbances are common in elderly and occur frequently in dementia. The impact of excessive daytime sleepiness (EDS), insomnia complaints, sleep quality, and hypnotics on the risk of all-cause dementia, Alzheimer disease (AD), and dementia with vascular component (DVC) remains unclear, as does the association between sleep profile and plasma beta-amyloid levels. Methods Analyses were carried out on 6851 participants aged 65 years and over randomly recruited from three French cities and free of dementia at baseline. A structured interview and self-questionnaire assessed sleep complaints (EDS, insomnia complaints, sleep quality) and medications at baseline. Incident cases of dementia were diagnosed systematically over a 12-year period. Multivariate Cox models were used to estimate the risk of dementia associated with the sleep complaints considered individually and globally. Plasma beta-amyloid levels were measured by an xMAP-based assay technology in 984 subjects. Results After adjustment for socio-demographic characteristics, lifestyle, APOE-epsilon 4, cardiovascular factors, and depressive status, EDS had a higher risk of all-cause dementia (HR = 1.21; 95%CI = [1.01-1.46]) and DVC (HR = 1.58; 95%CI = [1.07-2.32]) but not AD. Persistent use of hypnotics increased the risk for all-cause dementia, specifically AD (HR = 1.28; 95%CI = [1.04-1.58]), but not DVC. No association was found for insomnia complaints and sleep quality taken as individual factors or combined with EDS on the risk of dementia. No association was found between beta-amyloid, sleep complaints, and incident dementia. Conclusions The results suggest a deleterious role of EDS and hypnotics on dementia. Further studies are required to elucidate the mechanisms involved in these associations and whether its management can prevent the risk of dementia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据