期刊
ADVANCED HEALTHCARE MATERIALS
卷 11, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202101844
关键词
DNA nanotechnology; DNA origami; drug delivery; immune modulation; immune receptors; immunological synapses; immunotherapy
资金
- Canadian Institutes of Health Research
- Ontario Student Opportunity Trust Fund
- Institute of Biomedical Engineering at the University of Toronto
- PRiME initiative at the University of Toronto
- NSERC [RGPIN-2020-05966]
- Canadian Foundation of Innovation [39262]
- New Frontiers Exploration Fund [NFRFE-2018-01444]
- CFREF Medicine by Design initiative [MbDNI-2019-01, MbDNI-2020-01]
This article discusses the biophysical principles governing immune receptor signaling and activation, as well as the development of biomaterials for therapeutic immune engineering. The potential of DNA nanotechnology in immune engineering is further explored, primarily through the design of DNA nanostructures to manipulate immune signaling pathways and develop applications such as in vitro reconstitution platforms.
Immune cells sense, communicate, and logically integrate a multitude of environmental signals to make important cell-fate decisions and fulfill their effector functions. These processes are initiated and regulated by a diverse array of immune receptors and via their dynamic spatiotemporal organization upon ligand binding. Given the widespread relevance of the immune system to health and disease, there have been significant efforts toward understanding the biophysical principles governing immune receptor signaling and activation, as well as the development of biomaterials which exploit these principles for therapeutic immune engineering. Here, how advances in the field of DNA nanotechnology constitute a growing toolbox for further pursuit of these endeavors is discussed. Key cellular players involved in the induction of immunity against pathogens or diseased cells are first summarized. How the ability to design DNA nanostructures with custom shapes, dynamics, and with site-specific incorporation of diverse guests can be leveraged to manipulate the signaling pathways that regulate these processes is then presented. It is followed by highlighting emerging applications of DNA nanotechnology at the crossroads of immune engineering, such as in vitro reconstitution platforms, vaccines, and adjuvant delivery systems. Finally, outstanding questions that remain for further advancing immune-modulatory DNA nanodevices are outlined.
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