期刊
ADVANCED HEALTHCARE MATERIALS
卷 11, 期 12, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202200199
关键词
bacterial skin abscesses; cationic amphiphilic copolymers; electrostatic assembly; nitric oxide; photothermal effects
资金
- National Natural Science Foundation of China [32071394, 31771034]
Developing novel approaches to combat bacterial resistance is crucial. In this study, amphiphilic antimicrobial copolymers, black phosphorus quantum dots, and S-nitrosocysteamine are assembled into nanoparticles, achieving synergistic antibacterial efficacy. This approach shows promising potential in promoting wound recovery and suppressing inflammatory cells.
It is of paramount importance to develop novel approaches for combating bacterial resistance and the integration of different antibacterial mechanisms is essential to achieve synergistic bactericidal efficiency while reducing the associated side effects. Herein, amphiphilic antimicrobial copolymers derived from poly-l-lysine (PLL), black phosphorus quantum dots (BPQDs) as near-infrared (NIR) sensitizer, and S-nitrosocysteamine (SNO) as nitric oxide (NO) donor, are assembled into PELI@BPQD-SNO nanoparticles through electrostatic interactions. Amphiphilic copolymers with isopentanyl grafts on PLL at a ratio of 50% achieve an optimal balance between antibacterial activity and hemolysis rate. Photothermal effect of BPQDs leads to NIR-responsive release of NO and the combination with amphiphilic copolymers mutually enhances long-term inhibition of bacterial growth. In an S. aureus-infected subcutaneous abscess model, the bactericidal rate of PELI@BPQD-SNO/NIR treatment reaches nearly 99.6%, which is significantly higher than those without NO release (38%) or amphiphilic copolymers (24%) or NIR irradiation (17%). PELI@BPQD-SNO/NIR treatment shows full recovery of infected wounds, efficient retardation of inflammatory cells, and reconstruction of blood vessels similar to those of healthy skin. Therefore, the electrostatic assembly demonstrates a promising strategy to deliver charged therapeutic agents and the photoactivated release of NO and amphiphilic copolymers achieves synergistic antibacterial efficacy without using any antibiotics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据