期刊
ADVANCED HEALTHCARE MATERIALS
卷 11, 期 10, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202101931
关键词
bioactive materials; citric acid-based biomaterials; immunomodulation; tissue engineering
资金
- National Natural Science Foundation of China [52172288]
- Special Support Program for High Level Talents of Shaanxi Province of China [TZ0278]
- key R&D plan of Shaanxi Province of China [2021GXLH-Z-052]
- State Key Laboratory for Manufacturing Systems Engineering of China [sklms2021006]
- Young Talent Support Plan of Xi'an Jiaotong University of China [QY6J003]
This study reports on the important role and mechanism of a novel polymer in skin wound repair. The polymer is found to modulate macrophage phenotype and promote angiogenesis, thus accelerating skin wound healing. Additionally, the polymer exhibits good biocompatibility with immune cells and tissue cells. These findings contribute to a better understanding and application of citrate-based biomaterials in tissue engineering.
The inhibition of inflammation and the promotion of early angiogenesis are paid much attention in skin tissue engineering. Citric acid-based biomaterials are widely used in tissue engineering due to their bioactive structure and biocompatibility, but there are few studies on investigating their role and mechanism in wound repair and skin regeneration. Herein, the potential anti-inflammation mechanism of poly(octanediol-citrate-polyglycol) (POCG) copolymer is reported in regulating skin wound repair. It is found that POCG can modulate macrophages phenotype through downregulating the expression of proinflammatory cytokines (tumor necrosis facor-alpha (Tnf-alpha), Interleukin-1 beta (IL-1 beta), and Interleukin-6 (IL-6) and polarizing macrophages to anti-inflammatory (M2) phenotype. POCG can promote endothelial cell vascularization by increasing the expression of angiogenesis factors (vascular endothelial growth factor (Vegf) and cluster of differentiation 31CD31) mediated by the macrophage polarization. The in vivo study shows that POCG can accelerate skin wound repair through suppressing the acute inflammation and inducing early angiogenesis through the polarization modulation. Furthermore, the POCG polymer has good biocompatibility for both immune cells and tissue cells. This study may provide the important theoretical support on the bioactivity of citrate-based biomaterials and expanding their applications in tissue engineering.
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