期刊
ADVANCED HEALTHCARE MATERIALS
卷 11, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202101504
关键词
antibacterials; cyclic ketene acetal; cytocompatibility; degradable adhesives; gelatin; hydrogel adhesives; self-healing
资金
- China Postdoctoral Science Foundation [2019TQ0119]
- National Key Research and Development Program of China [2016YFA0101102]
- Hubei Province Technological Innovation Major Project [2019AAA034]
- Excellent Young Science and Technology Innovation Team of Hubei High School [T201707]
- Project of Wuhan Science and Technology Bureau [2019010702011335]
Degradable hydrogel adhesives with multifunctional advantages, including degradability, antibacterial property, and fast self-healing, show great potential as tissue adhesives in the biomedical field.
Degradable hydrogel adhesives with multifunctional advantages are promising to be candidates as hemostatic agents, surgical sutures, and wound dressings. In this study, hydrogel adhesives are constructed by catechol-conjugated gelatin from natural resource, iron ions (Fe3+), and a synthetic polymer. Specifically, the latter is prepared by the radical ring-opening copolymerization of a cyclic ketene acetal monomer 5,6-benzo-2-methylene-1,3-dioxepane and N-(2-ethyl p-toluenesulfonate) maleimide. By the incorporation of ester bonds in the backbone and the combination with quaternary ammonium salt pendants in the polymer, it exhibits excellent degradability and antibacterial property. Remarkably, doping the synthetic polymer into the 3,4-dihydroxyphenylacetic acid-modified gelatin network forms a semi-interpenetrating polymer network which can effectively improve the rigidity, tissue adhesion, and antibacterial property of fabricated hydrogel adhesives. Moreover, non-covalent bonds from coordination interaction between catechol and Fe3+ contribute to the fast self-healing of the developed hydrogel adhesives. These hydrogel adhesives with the multiple merits including the degradability, enhanced tissue adhesion, superior self-healing, good cytocompatibility, and antibacterial property show the great potential to be used as tissue adhesives in biomedical fields.
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