期刊
ACS MACRO LETTERS
卷 11, 期 2, 页码 179-185出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.1c00706
关键词
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资金
- National Natural Science Foundation of China (NSFC) [21971052, 22071041, 21871073, 51803045]
- Fundamental Research Funds for the Central Universities of China [PA2019GDPK0057, PA2020GDJQ0028]
In this study, a strategy to synthesize well-defined bottlebrush polymers was reported, which showed great potential in drug delivery.
In this work, we reported a strategy to synthesize well-defined bottlebrush polymers. Diazoacetate macromonomers of polystyrene (1-PS,,) with controlled molecular weights were prepared via reversible addition- fragmentation chain transfer (RAFT) polymerization. The diazo can tolerate the RAFT polymerization conditions and remained on the chain end of the yielded PS macromonomer. The terminal diazo groups of the macromonomer were polymerized by the allyl PdCl/L catalyst to afford welldefined bottlebrush polymers ((1-PS,,)ms) carrying a side chain on each backbone atom. Meanwhile, an amphiphilic bottlebrush polymer containing brush-shaped PS and polyethylene glycol (PEG) was synthesized by polymerization of the diazoacetate macromonomer of PEG (2-PEG) using Pd(II)-terminated (1-PS,,)m as the macroinitiator. The yielded amphiphilic (1-PS30)50-b-(2-PEG)100 could self assemble into a well-defined core-shell micelle in aqueous solutions. The hydrodynamic diameter of the micelle was ca. 146 nm and had good biocompatibility. These results indicate the micelles have great potential in drug delivery.
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