期刊
WORLD NEUROSURGERY
卷 160, 期 -, 页码 102-+出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.wneu.2021.11.083
关键词
Acoustic neuroma; Gamma Knife radiosurgery; Hearing preservation; Microsurgery; Stereotactic radiosurgery; Tumor control; Vestibular schwannoma
A meta-analysis comparing the outcomes of sporadic vestibular schwannoma patients treated with stereotactic radiosurgery (SRS) or microsurgery (MS) revealed comparable results in hearing preservation and tumor control, but a higher occurrence of facial nerve dysfunction in the microsurgery group.
BACKGROUND: A meta-analysis of patients with sporadic vestibular schwannoma (VS) primarily treated with stereotactic radiosurgery (SRS) or microsurgery (MS) was performed, and hearing preservation outcome (HPO), tumor control (TC), and facial nerve dysfunction (FND) were analyzed. METHODS: A systematic review was conducted (Medline and Scopus database) for the period January 2010-June 2020 with appropriate MeSH. English language articles for small to medium sporadic VS (<3 cm) using SRS or MS as primary treatment modality, with minimum follow-up of 3 years, were included. Studies had to report an acceptable standardized hearing metric. RESULTS: Thirty-two studies met the inclusion criteria: 10 MS; 23 radiosurgery, and 1 comparative study included in both. HPO, at approximately 65 months follow-up, were comparable between MS group (10 studies; 809 patients) and SRS group (23 studies; 1234 patients) (56% vs. 59%; P = 0.1527). TC, at approximately 70 months follow-up, was significantly better in the MS group (9 studies; 1635 patients) versus the SRS group (19 studies; 2260 patients) (98% vs. 92%; P < 0.0001). FND, at approximately 12 months follow-up, was significantly higher in the MS group (8 studies; 1101 patients) versus the SRS group (17 studies; 2285 patients) (10% vs. 2%; P < 0.0001). CONCLUSIONS: MS and SRS are comparable primary treatments for small (<3 cm) sporadic VS with respect to HPO at 5-year follow-up in patients with serviceable hearing at presentation; approximately 50% of patients for both modalities likely lose serviceable hearing by that time point. High TC rates (> 90%) were seen with both modalities; MS 98% versus SRS 92%. The post-treatment FND was significantly less with the SRS group (2%) versus the MS group (10%).
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