期刊
VIRULENCE
卷 13, 期 1, 页码 89-121出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21505594.2021.2019950
关键词
Candida albicans; candidiasis; pathogenesis; virulence; immunity; host-pathogen interactions
资金
- Division of Intramural Research of the National Institute of Allergy and Infectious Diseases, NIH
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases [ZIA AI001175]
This review synthesizes our current knowledge of tissue-specific determinants of Candida albicans pathogenicity and host immune defense mechanisms.
Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic immunosuppression, and/or medical interventions that impair the integrity of the mucocutaneous barrier and/or perturb protective host defense mechanisms enable C. albicans to become an opportunistic pathogen and cause debilitating mucocutaneous disease and/or life-threatening systemic infections. In this review, we synthesize our current knowledge of the tissue-specific determinants of C. albicans pathogenicity and host immune defense mechanisms.
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