期刊
TRAVEL MEDICINE AND INFECTIOUS DISEASE
卷 44, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.tmaid.2021.102200
关键词
Sars-Cov-2; ApoA; ApoB; Prognosis; Mortality
资金
- Universidad Peruana de Ciencias Aplicadas [IP008-2016]
The study found that low levels of plasma apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB) in COVID-19 patients are associated with increased risk of developing severe disease, while the ApoB/ApoA1 ratio does not show a significant association with severity. Additionally, low ApoA1 levels are linked to higher all-cause mortality rates.
Introduction: Apolipoproteins are predictive biomarkers for cardiovascular, neoplasms and cerebrovascular diseases and are postulated as prognostic biomarkers in infectious diseases, as COVID-19. Thus, we assessed the prognosis value of apolipoproteins for COVID-19 severity and mortality. Methods: We conducted a systematic review and meta-analysis using observational studies that reported the association between apolipoproteins and severity or mortality in COVID-19 patients. Newcastle-Ottawa was used for the quality assessment of included studies. Effects measurements were shown as odds ratios (ORs) with 95% confidence intervals (CIs), and Egger-test was developed for assessing the risk of bias publication. Results: We analyzed 12 cohort studies (n = 3580). Patients with low ApoliproteinA1 (ApoA1) (OR 0.35; 95%CI 0.24 to 0.49; P < 0.001) and ApoliproteinB (ApoB) (OR = 0.78; 95%CI 0.69 to 0.87; P < 0.001) values had a higher risk of developing severe disease. ApoB/ApoA1 ratio showed no statistically significant association with higher odds of severity. Low ApoA1 levels were associated with higher odds of all-cause mortality (OR = 0.34; 95%CI 0.20 to 0.57; P < 0.001). ApoB values showed no statistically significant association with a high risk of allcause mortality. Conclusion: We suggest that adequate levels of ApoA1 and ApoB can be a protective factor for severity in COVID19, and ApoB/ApoA1 ratio did not show predictive utility for severity.
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