Application of stem cells in the repair of intervertebral disc degeneration

Intervertebral disc degeneration (IDD) is a common disease that increases with age, and its occurrence is stressful both psychologically and financially. Stem cell therapy for IDD is emerging. For this therapy, stem cells from different sources have been proven in vitro, in vivo, and in clinical trials to relieve pain and symptoms, reverse the degeneration cascade, delay the aging process, maintain the spine shape, and retain mechanical function. However, further research is needed to explain how stem cells play these roles and what effects they produce in IDD treatment. This review aims to summarize and objectively analyse the current evidence on stem cell therapy for IDD.

Automated summary

Stem cell therapy for intervertebral disc degeneration is emerging as a potential treatment option, with evidence from in vitro, in vivo, and clinical trials showing its effectiveness in relieving pain and symptoms, reversing the degenerative cascade, delaying the aging process, and maintaining spinal function. Further research is needed to understand the mechanisms and effects of stem cells in IDD treatment.