期刊
STEM CELL RESEARCH & THERAPY
卷 12, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13287-021-02635-9
关键词
Mesenchymal stem cells; Rheumatic diseases; Clinical application
资金
- National Natural Science Foundation of China [81771768, 82001741]
- applied basic research project of Shanxi Science and Technology Department [201801D221381]
Mesenchymal stem cells have great application value in cell replacement therapy and tissue repair, and their application in the treatment of rheumatic diseases is receiving increasing attention. These cells have the ability to differentiate into various cell types and are involved in immune regulation, inflammation alleviation, anti-fibrotic properties, and vascular repair.
Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from mesoderm during early development that are characterized by high self-renewal ability and multidirectional differentiation potential. These cells are present various tissues in the human body and can be cultured in vitro. Under specific conditions, MSCs can differentiate into osteoblasts, neuron-like cells, adipocytes and muscle cells and so on, therefore, have a great application value in cell replacement therapy and tissue repair. In recent years, the application of MSCs in rheumatic diseases has received increasing attention. On the one hand, MSCs have the ability to differentiate into bone and cartilage cells; on the other hand, these stem cells are also involved in immune regulation, resulting in the alleviation of inflammation and anti-fibrotic properties and the promotion of vascular repair, thus bringing new hope for the treatment of rheumatic diseases. This article reviews the clinical progress in MSC application for the treatment of rheumatic diseases.
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