Constructing a cell microenvironment with biomaterial scaffolds for stem cell therapy

Stem cell therapy is widely recognized as a promising strategy for exerting therapeutic effects after injury in degenerative diseases. However, limitations such as low cell retention and survival rates after transplantation exist in clinical applications. In recent years, emerging biomaterials that provide a supportable cellular microenvironment for transplanted cells have optimized the therapeutic efficacy of stem cells in injured tissues or organs. Advances in the engineered microenvironment are revolutionizing our understanding of stem cell-based therapies by co-transplanting with synthetic and tissue-derived biomaterials, which offer a scaffold for stem cells and propose an unprecedented opportunity to further employ significant influences in tissue repair and regeneration.

Automated summary

Stem cell therapy is recognized as a promising strategy for treating degenerative diseases, but low cell retention and survival rates limit its clinical applications. Emerging biomaterials that provide a supportive cellular microenvironment have optimized the therapeutic efficacy of stem cells in injured tissues. Advances in engineered microenvironment, through co-transplanting with synthetic and tissue-derived biomaterials, offer unprecedented opportunities for significant influences in tissue repair and regeneration.