4.7 Article

Total synthesis of (±)-decursivine via BINOL-phosphoric acid catalyzed tandem oxidative cyclization

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SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -

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NATURE PORTFOLIO
DOI: 10.1038/s41598-021-99064-8

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  1. National Institutes of Health [GM097118, AI090662]

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The synthesis of tetracyclic indole alkaloid (+/-)-decursivine was achieved through a tandem oxidative cyclization catalyzed by BINOL-phosphoric acid, using (bis(trifluoroacetoxy)iodo)benzene (PIFA) as an oxidizing agent. This represents a short and high-yielding route for the synthesis of (+/-)-decursivine from readily available starting materials.
The synthesis of tetracyclic indole alkaloid (+/-)-decursivine was accomplished using BINOL-phosphoric acid catalyzed tandem oxidative cyclization as a key step with (bis(trifluoroacetoxy)iodo)benzene (PIFA) as an oxidizing agent. This represents one of the shortest and highest yielding routes for the synthesis of (+/-)-decursivine from readily available starting materials.

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