Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction

Asthma is a complex disease that is reportedly associated with insomnia. However, the causal directionality of this association is still unclear. We used asthma and insomnia-associated single nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) summary statistics to test the causal directionality between insomnia and asthma via Mendelian randomization (MR) analysis. We also performed a cross-trait meta-analysis using UK Biobank GWAS summary statistics and a gene-environment interaction study using data from UK Biobank. The interaction of genetic risk score for asthma (GRS(asthma)) with insomnia on asthma was tested by logistic regression. Insomnia was a risk factor for the incidence of asthma, as revealed by three different methods of MR analysis. However, asthma did not act as a risk factor for insomnia. The cross-trait meta-analysis identified 28 genetic loci shared between asthma and insomnia. In the gene-environment interaction study, GRS(asthma) interacted with insomnia to significantly affect the risk of asthma. The results of this study highlight the importance of insomnia as a risk factor of asthma, and warrant further analysis of the mechanism through which insomnia affects the risk of asthma.

Automated summary

Insomnia is identified as a risk factor for asthma, while asthma does not contribute to the development of insomnia. The cross-trait meta-analysis revealed 28 genetic loci shared between asthma and insomnia. The gene-environment interaction study demonstrated the significant impact of the genetic risk score for asthma on the risk of asthma in conjunction with insomnia.