期刊
SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-01938-4
关键词
-
资金
- EU [005/2015]
- Spanish MINECO (NACE Project) [CTM2016-81130-R]
- Basque Government [IT1302-19]
In this study, it was found that polystyrene nanoparticles and microplastics can act as carriers for transferring benzo(a)pyrene to mussel hemocytes, potentially posing risks to aquatic organisms. The presence of BaP reduced particle aggregation and both plastics and BaP showed cytotoxic effects on hemocytes.
In this work we studied the ability of polystyrene (PS) nanoplastics (NPs) and microplastics (MPs) to transfer benzo(a)pyrene (BaP) to mussel hemocytes and to produce toxic effects in vitro. For this, intracellular fate and toxicity of PS NPs (0.05 mu m) and MPs (0.5 and 4.5 mu m) alone or with BaP and of BaP alone were assessed. Particles of 0.05 and 0.5 mu m largely aggregated in the exposure medium whereas presence of BaP reduced particle aggregation. Cells internalized PS NPs and MPs alone or with BaP and these were found inside and outside lysosomes, depending on their size. PS particles alone or with BaP were cytotoxic to hemocytes only at the highest concentrations tested. The same was true for most sublethal endpoints except for increased phagocytic activity provoked by NPs and 0.5 mu m MPs at lower concentrations. Plastic particles appeared to be the main drivers for reduced plasma membrane integrity and increased phagocytic and lysosomal activities whereas BaP appeared to contribute more to reduced cell viability and phagocytosis and increased ROS production and genotoxicity. Overall, PS NPs and MPs can act as carriers of BaP to mussel hemocytes, rising concerns about risks plastics associated to pollutants may pose to aquatic organisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据