期刊
SCIENTIFIC REPORTS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-05492-5
关键词
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资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Japan Society for the Promotion of Science
- Japan Agency for Medical Research and Development
- Ministry of Health, Labour, and Welfare of Japan [20fk0210072h0001, 20fk0210058h0002, 20fk0210048h0002]
- Gilead Sciences Inc.
- Bristol Myers Squibb
Liver stiffness measurement is a useful tool in assessing liver fibrosis. This study identifies age and liver stiffness as important risk factors for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. Low-risk individuals have a lower incidence of HCC.
Liver stiffness measurement (LSM) is a useful tool for assessing advanced liver fibrosis, an important risk factor for hepatocellular carcinoma (HCC) following hepatitis C (HCV) eradication. This study aimed to clarify the non-invasive factors associated with HCC following sustained virological response (SVR) and to identify the low-risk group. 567 patients without history of HCC who achieved SVR at 24 weeks (SVR24) after IFN-free treatment were retrospectively analyzed. The cumulative incidence of HCC and the risk factors were examined using pre-treatment and SVR24 data. The median observation period was 50.2 months. Thirty cases of HCC were observed, and the 4-year cumulative incidence of HCC was 5.9%. In multivariate analysis, significant pre-treatment factors were age >= 71 years (hazard ratio [HR]: 3.402) and LSM >= 9.2 kPa (HR: 6.328); SVR24 factors were age >= 71 years (HR: 2.689) and LSM >= 8.4 kPa (HR: 6.642). In cases with age < 71 years and LSM < 8.4 kPa at the time of SVR24, the 4-year cumulative incidence of HCC was as low as 1.1%. Both pre-treatment LSM (>= 9.2 kPa) and SVR24 LSM (>= 8.4 kPa) and age (>= 71 years) are useful in predicting the risk of HCC after SVR with IFN-free treatment. Identification of low-risk individuals may improve the efficiency of follow-up.
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