4.6 Article

Hybrid hydrogels derived from renewable resources as a smart stimuli responsive soft material for drug delivery applications

期刊

RSC ADVANCES
卷 12, 期 4, 页码 2009-2018

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ra08447j

关键词

-

资金

  1. Science and Engineering Research Board, Department of Science and Technology, India [CRG/2018/001386]
  2. SPARC, Ministry of Human Resource Development, India [SPARC/2018-2019/P263/SL]

向作者/读者索取更多资源

The design and synthesis of amphiphilic molecules play a crucial role in fabricating smart functional materials via self-assembly, especially the inspiration from biologically significant natural molecules and their analogues. In this study, a series of amphiphilic N-acyl amides were synthesized from natural precursors using a simple synthetic protocol. The self-assembly of these molecules in vegetable oils resulted in the formation of hydrogel and oleogel, exhibiting unique morphological features and thermoresponsive behavior.
The design and synthesis of amphiphilic molecules play a crucial role in fabricating smart functional materials via self-assembly. Especially, biologically significant natural molecules and their structural analogues have inspired chemists and made a major contribution to the development of advanced smart materials. In this report, a series of amphiphilic N-acyl amides were synthesized from natural precursors using a simple synthetic protocol. Interestingly, the self-assembly of amphiphiles 6a and 7a furnished a hydrogel and oleogel in vegetable oils. Morphological analysis of gels revealed the existence of a 3-dimensional fibrous network. Thermoresponsive and thixotropic behavior of these gels were evaluated using rheological analysis. A composite gel prepared by the encapsulation of curcumin in the hydrogel formed from 7a displayed a gel-sol transition in response to pH and could act as a dual channel responsive drug carrier.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据