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Emerging Evidence for the Widespread Role of Glutamatergic Dysfunction in Neuropsychiatric Diseases

NUTRIENTS (2022)

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Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study

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MICROBIOME (2017)

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Review Clinical Neurology

Microbiota-Brain-Gut Axis and Neurodegenerative Diseases

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CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2017)

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Psoriasis, Depression, and Inflammatory Overlap: A Review

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AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2017)

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LANCET PSYCHIATRY (2017)

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Review Clinical Neurology

Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut-brain pathways

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CNS SPECTRUMS (2016)

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Article Gastroenterology & Hepatology

Similar Fecal Microbiota Signatures in Patients With Diarrhea-Predominant Irritable Bowel Syndrome and Patients With Depression

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CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2016)

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Article Psychiatry

Exercise as a treatment for depression: A meta-analysis adjusting for publication bias

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JOURNAL OF PSYCHIATRIC RESEARCH (2016)

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Article Clinical Neurology

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and infl ammation

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Review Biochemistry & Molecular Biology

The Gut-Brain Axis, BDNF, NMDA and CNS Disorders

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NEUROCHEMICAL RESEARCH (2016)

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Article Neurosciences

Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors

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NEURON (2016)

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Alterations of the human gut microbiome in multiple sclerosis

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NATURE COMMUNICATIONS (2016)

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Review Nutrition & Dietetics

Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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NUTRIENTS (2016)

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Article Psychiatry

Nature of Glutamate Alterations in Schizophrenia A Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies

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JAMA PSYCHIATRY (2016)

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Review Psychology, Developmental

A systematic review of the behavioural outcomes following exercise interventions for children and youth with autism spectrum disorder

Emily Bremer et al.

AUTISM (2016)

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Fever and sickness behavior: Friend or foe?

L. M. Harden et al.

BRAIN BEHAVIOR AND IMMUNITY (2015)

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Article Clinical Neurology

Oral fingolimod reduces glutamate-mediated intracortical excitability in relapsing-remitting multiple sclerosis

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CLINICAL NEUROPHYSIOLOGY (2015)

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Review Biochemistry & Molecular Biology

A Review on GABA/Glutamate Pathway for Therapeutic Intervention of ASD and ADHD

Priyanka Purkayastha et al.

CURRENT MEDICINAL CHEMISTRY (2015)

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Risk factors for suicide in bipolar disorder: A systematic review

Lucas da Silva Costa et al.

JOURNAL OF AFFECTIVE DISORDERS (2015)

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Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Edwin B. Yan et al.

JOURNAL OF NEUROINFLAMMATION (2015)

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Review Clinical Neurology

Glutamate and dopamine in schizophrenia: An update for the 21st century

Oliver Howes et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2015)

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Article Neurosciences

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

Victor S. Van Laar et al.

NEUROBIOLOGY OF DISEASE (2015)

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A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

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NEURON (2015)

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Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice

Tomomi Aida et al.

NEUROPSYCHOPHARMACOLOGY (2015)

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Review Behavioral Sciences

The association between autism and schizophrenia spectrum disorders: A review of eight alternate models of co-occurrence

Katharine Chisholm et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2015)

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Article Clinical Neurology

Hippocampal glutamatergic/NMDA receptor functioning in bipolar disorder: A study combining mismatch negativity and proton magnetic resonance spectroscopy

Kate M. Chitty et al.

PSYCHIATRY RESEARCH-NEUROIMAGING (2015)

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Review Neurosciences

Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?

Jan Lewerenz et al.

FRONTIERS IN NEUROSCIENCE (2015)

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Article Medicine, Research & Experimental

Immunomodulatory Effects of Probiotic Supplementation in Schizophrenia Patients: A Randomized, Placebo-Controlled Trial

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BIOMARKER INSIGHTS (2015)

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Article Psychology, Clinical

Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression: A Systematic Review and Meta-Analysis

Bradley N. Gaynes et al.

JOURNAL OF CLINICAL PSYCHIATRY (2014)

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Review Clinical Neurology

Glutamate as a neurotransmitter in the healthy brain

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JOURNAL OF NEURAL TRANSMISSION (2014)

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Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain

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JOURNAL OF NEUROSCIENCE (2014)

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Review Clinical Neurology

The emerging role of dopamine-glutamate interaction and of the postsynaptic density in bipolar disorder pathophysiology: Implications for treatment

Andrea de Bartolomeis et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2014)

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Editorial Material Multidisciplinary Sciences

Put therapies first

Lisa M. Monteggia

NATURE (2014)

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Review Behavioral Sciences

Stress and glucocorticoid receptor-dependent, mechanisms in long-term memory: From adaptive responses to psychopathologies

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NEUROBIOLOGY OF LEARNING AND MEMORY (2014)

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Article Psychology, Clinical

Extensive brain structural network abnormality in first-episode treatment-naive patients with schizophrenia: morphometrical and covariation study

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PSYCHOLOGICAL MEDICINE (2014)

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Article Endocrinology & Metabolism

Association of pro-inflammatory cytokines, cortisol and depression in patients with chronic obstructive pulmonary disease

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PSYCHONEUROENDOCRINOLOGY (2014)

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IL-6 in Inflammation, Immunity, and Disease

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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

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Review Rehabilitation

Systematic Review of the Effects of Exercise on Activities of Daily Living in People With Alzheimer's Disease

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AMERICAN JOURNAL OF OCCUPATIONAL THERAPY (2014)

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Review Pharmacology & Pharmacy

PET and SPECT tracers for glutamate receptors

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DRUG DISCOVERY TODAY (2013)

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Review Clinical Neurology

A systematic review and meta-analysis of proton magnetic resonance spectroscopy and mismatch negativity in bipolar disorder

Kate M. Chitty et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2013)

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Article Clinical Neurology

Dances with black widow spiders: Dysregulation of glutamate signalling enters centre stage in ADHD

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EUROPEAN NEUROPSYCHOPHARMACOLOGY (2013)

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Article Biochemistry & Molecular Biology

The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)

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MOLECULAR PSYCHIATRY (2013)

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Article Multidisciplinary Sciences

Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Clinical Neurology

Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: A preliminary study

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PSYCHIATRY RESEARCH-NEUROIMAGING (2013)

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Review Psychology, Clinical

Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies

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PSYCHOLOGICAL MEDICINE (2013)

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Article Psychiatry

Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of H-1-MRS Studies

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SCHIZOPHRENIA BULLETIN (2013)

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Review Gastroenterology & Hepatology

Current pathogenetic aspects of hepatic encephalopathy and noncirrhotic hyperammonemic encephalopathy

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Review Neurosciences

Microglia Control Neuronal Network Excitability via BDNF Signalling

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NEURAL PLASTICITY (2013)

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Article Endocrinology & Metabolism

Glutamate Pays Its Own Way in Astrocytes

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Frontiers in Endocrinology (2013)

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Epidemiology of depression and diabetes: A systematic review

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Pretreatment with alanyl-glutamine suppresses T-helper-cell-associated cytokine expression and reduces inflammatory responses in mice with acute DSS-induced colitis

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Article Medicine, General & Internal

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

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Review Behavioral Sciences

Region and state specific glutamate downregulation in major depressive disorder: A meta-analysis of H-1-MRS findings

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Article Multidisciplinary Sciences

Elevated Glutamatergic Compounds in Pregenual Anterior Cingulate in Pediatric Autism Spectrum Disorder Demonstrated by 1H MRS and 1H MRSI

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PLOS ONE (2012)

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Prevalence and Correlates of Bipolar Spectrum Disorder in the World Mental Health Survey Initiative

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ARCHIVES OF GENERAL PSYCHIATRY (2011)

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In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism

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BRAIN RESEARCH (2011)

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GABAergic and Glutamatergic Modulation in Binge Eating: Therapeutic Approach

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CURRENT PHARMACEUTICAL DESIGN (2011)

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Determination of Factors Affecting Glutamate Concentrations in the Whole Blood of Healthy Human Volunteers

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Reduced anxiety-like behavior and central neurochemical change in germ-free mice

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NEUROGASTROENTEROLOGY AND MOTILITY (2011)

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EXERCISE PRECONDITIONING AND BRAIN ISCHEMIC TOLERANCE

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Encephalopathies: the emerging diabetic complications

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ACTA DIABETOLOGICA (2010)

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Review Psychiatry

Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

Alan S. Brown et al.

AMERICAN JOURNAL OF PSYCHIATRY (2010)

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A Meta-Analysis of Cytokines in Major Depression

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BIOLOGICAL PSYCHIATRY (2010)

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Editorial Material Neurosciences

How GABA generates depolarization

Nicholas C. Spitzer

JOURNAL OF PHYSIOLOGY-LONDON (2010)

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Article Neurosciences

Association between Plasma IL-6 Response to Acute Stress and Early-Life Adversity in Healthy Adults

Linda L. Carpenter et al.

NEUROPSYCHOPHARMACOLOGY (2010)

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Article Nutrition & Dietetics

The blood-brain barrier and glutamate

Richard A. Hawkins

AMERICAN JOURNAL OF CLINICAL NUTRITION (2009)

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Adverse Childhood Experiences and the Risk of Premature Mortality

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AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2009)

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Review Neurosciences

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

Andrew H. Miller et al.

BIOLOGICAL PSYCHIATRY (2009)

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Article Psychology, Multidisciplinary

Social-Evaluative Threat and Proinflammatory Cytokine Regulation: An Experimental Laboratory Investigation

Sally S. Dickerson et al.

PSYCHOLOGICAL SCIENCE (2009)

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Article Multidisciplinary Sciences

Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease

Mark P. Mattson

NEURAL SIGNALING: OPPORTUNITIES FOR NOVEL DIAGNOSTIC APPROACHES AND THERAPIES (2008)

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Article Biochemistry & Molecular Biology

AMPA receptor subunit 1 (GluR-A) knockout mice model the glutamate hypothesis of depression

S. Chourbaji et al.

FASEB JOURNAL (2008)

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Article Radiology, Nuclear Medicine & Medical Imaging

Quantitation of glutamate in the brain by using MR proton spectroscopy at 1.5 T and 3 T

A. Gussew et al.

ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN (2008)

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Article Neurosciences

Maternal immune activation alters fetal brain development through interleukin-6

Stephen E. P. Smith et al.

JOURNAL OF NEUROSCIENCE (2007)

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Review Biochemistry & Molecular Biology

The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer

Lasse K. Bak et al.

JOURNAL OF NEUROCHEMISTRY (2006)

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Article Neurosciences

Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting

Conor Liston et al.

JOURNAL OF NEUROSCIENCE (2006)

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Article Biochemistry & Molecular Biology

Dietary glutamine supplementation modulates Th1/Th2 cytokine and interleukin-6 expressions in septic mice

CL Yeh et al.

CYTOKINE (2005)

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Article Biochemistry & Molecular Biology

Altered neuronal-glial signaling in glutamatergic transmission as a unifying mechanism in chronic pain and mental fatigue

E Hansson et al.

NEUROCHEMICAL RESEARCH (2004)

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Review Biochemistry & Molecular Biology

Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease

MR Hynd et al.

NEUROCHEMISTRY INTERNATIONAL (2004)

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Article Neurosciences

Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice

N Sudo et al.

JOURNAL OF PHYSIOLOGY-LONDON (2004)

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Article Neurosciences

Lower cortisol levels in depressed patients with comorbid post-traumatic stress disorder

MA Oquendo et al.

NEUROPSYCHOPHARMACOLOGY (2003)

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Article Multidisciplinary Sciences

A mechanism converting psychosocial stress into mononuclear cell activation

A Bierhaus et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Review Sport Sciences

Glutamine supplementation in vitro and in vivo, in exercise and in immunodepression

LM Castell

SPORTS MEDICINE (2003)

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Article Pharmacology & Pharmacy

Double-blind placebo-controlled pilot study of sertraline in military veterans with posttraumatic stress disorder

J Zohar et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2002)

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Review Endocrinology & Metabolism

An energy budget for signaling in the grey matter of the brain

D Attwell et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2001)

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Review Biochemistry & Molecular Biology

The relation between glutamine and the immunodepression observed in exercise

LM Castell et al.

AMINO ACIDS (2001)

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Article Neurosciences

Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK-801) injures pyramidal neurons in rat retrosplenial cortex

S Tomitaka et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2000)

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Article Nutrition & Dietetics

Glutamate as a neurotransmitter in the brain: Review of physiology and pathology

BS Meldrum

JOURNAL OF NUTRITION (2000)

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Article Neurosciences

Antidepressant effects of ketamine in depressed patients

RM Berman et al.

BIOLOGICAL PSYCHIATRY (2000)

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Article Endocrinology & Metabolism

Effect of interleukin-6 and tumor necrosis factor-alpha on GABA release from mediobasal hypothalamus and posterior pituitary

A De Laurentiis et al.

NEUROIMMUNOMODULATION (2000)

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