期刊
NUTRIENTS
卷 14, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/nu14020274
关键词
probiotics; SARS-CoV-2; COVID-19; gut-lung axis; microbiome; computational approach; molecular docking
资金
- Institutional Fund Projects [IFPRP:57-130-1442]
- Ministry of Education
- King Abdulaziz University, DSR, Jeddah, Saudi Arabia
This article discusses the possibility of using probiotics and their metabolites as adjunctive treatment for COVID-19. By regulating the gut microbiota, probiotics can restore a stable gut environment and combat the adverse effects of COVID-19. Clinical trials have shown the efficacy of probiotics and their metabolites in treating SARS-CoV-2, but their molecular mechanism has not been fully understood.
Coronavirus disease 2019 (COVID-19) was declared a pandemic at the beginning of 2020, causing millions of deaths worldwide. Millions of vaccine doses have been administered worldwide; however, outbreaks continue. Probiotics are known to restore a stable gut microbiota by regulating innate and adaptive immunity within the gut, demonstrating the possibility that they may be used to combat COVID-19 because of several pieces of evidence suggesting that COVID-19 has an adverse impact on gut microbiota dysbiosis. Thus, probiotics and their metabolites with known antiviral properties may be used as an adjunctive treatment to combat COVID-19. Several clinical trials have revealed the efficacy of probiotics and their metabolites in treating patients with SARS-CoV-2. However, its molecular mechanism has not been unraveled. The availability of abundant data resources and computational methods has significantly changed research finding molecular insights between probiotics and COVID-19. This review highlights computational approaches involving microbiome-based approaches and ensemble-driven docking approaches, as well as a case study proving the effects of probiotic metabolites on SARS-CoV-2.
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