4.7 Article

Dietary Barley Leaf Mitigates Tumorigenesis in Experimental Colitis-Associated Colorectal Cancer

期刊

NUTRIENTS
卷 13, 期 10, 页码 -

出版社

MDPI
DOI: 10.3390/nu13103487

关键词

barley leaf; colitis; colorectal cancer; intestinal barrier function; gut microbiota

资金

  1. Chinese National Key Research and Development Program [2017YFD0400705]
  2. National Natural Science Foundation of China [32001677]
  3. China Postdoctoral Science Foundation [2020M680256]
  4. Beijing Municipal Science and Technology Project Fund [D161100005416001]

向作者/读者索取更多资源

The study found that barley leaf supplementation can prevent colorectal cancer by reducing weight loss, inhibiting tumor formation, improving tissue damage, reducing cell proliferation and gene expression levels, and promoting the enrichment of Bifidobacterium.
Dietary barley (Hordeum vulgare L.) leaf (BL) is a popular functional food known to have potential health benefits; however, the effect of BL in colorectal cancer prevention has not been examined. Here, we examined the role of BL on the prevention of colorectal carcinogenesis and defined the mechanism involved. BL supplementation could protect against weight loss, mitigate tumor formation, and diminish histologic damage in mice treated with azoxymethane (AOM) and dextran sulfate sodium (DSS). Moreover, BL suppressed colonic expression of inflammatory enzymes, while improving the mucosal barrier dysfunctions. The elevated levels of cell proliferation markers and the increased expression of genes involved in beta-catenin signaling were also reduced by BL. In addition, analyses of microbiota revealed that BL prevented AOM/DSS-induced gut microbiota dysbiosis by promoting the enrichment of Bifidobacterium. Overall, these data suggest that BL is a promising dietary agent for preventing colitis-associated colorectal cancer.

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