4.7 Article

Association of Habitual Dietary Intake with Liver Iron-A Population-Based Imaging Study

期刊

NUTRIENTS
卷 14, 期 1, 页码 -

出版社

MDPI
DOI: 10.3390/nu14010132

关键词

liver iron; diet; MRI; nutrition; iron metabolism; alcohol; liver iron overload; population-based

资金

  1. HGF Future Topic AMPro
  2. Helmholtz Zentrum Munchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
  3. State of Bavaria
  4. Munich Center of Health Sciences (MC-Health)
  5. Ludwig-Maximilians University, as part of LMUinnovativ
  6. German Research Foundation (DFG, Deutsche Forschungsgemeinschaft) [BA 4233/4-1]
  7. Siemens Healthcare

向作者/读者索取更多资源

Iron-related disorders of the liver can result in serious health conditions, such as liver cirrhosis. This study aimed to assess the association between habitual diet and liver iron content (LIC) in 303 participants. The results showed that there are sex-specific associations of dietary intake with LIC, with alcohol, fiber, and potassium playing a considerable role in liver iron metabolism.
Iron-related disorders of the liver can result in serious health conditions, such as liver cirrhosis. Evidence on the role of modifiable lifestyle factors like nutrition in liver iron storage is lacking. Thus, we aimed to assess the association of habitual diet with liver iron content (LIC). We investigated 303 participants from the population-based KORA-MRI study who underwent whole-body magnetic resonance imaging (MRI). Dietary habits were evaluated using repeated 24 h food lists and a food frequency questionnaire. Sex-stratified multiple linear regression models were applied to quantify the association between nutrition variables of interest and LIC, adjusting for liver fat content (LFC), energy intake, and age. Mean age of participants was 56.4 +/- 9.0 years and 44.2% were female. Mean LIC was 1.23 +/- 0.12 mg/g dry weight, with higher values in men than in women (1.26 +/- 0.13 and 1.20 +/- 0.10 mg/g, p < 0.001). Alcohol intake was positively associated with LIC (men: beta = 1.94; women: beta = 4.98, p-values < 0.03). Significant negative associations with LIC were found for fiber (beta = -5.61, p < 0.001) and potassium (beta = -0.058, p = 0.034) for female participants only. Furthermore, LIC was highly correlated with liver fat content in both sexes. Our findings suggests that there are sex-specific associations of habitual dietary intake and LIC. Alcohol, fiber, and potassium may play a considerable role in liver iron metabolism.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据