期刊
NUTRIENTS
卷 14, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/nu14020256
关键词
COVID-19; SARS-CoV-2; symptoms; cytokine storm; curcumin; systematic review
This systematic review investigates the efficacy of curcumin supplementation in COVID-19 patients. The findings suggest that curcumin supplementation can significantly decrease symptoms, duration of hospitalization, and deaths. It also shows that curcumin helps balance pro-inflammatory and anti-inflammatory factors, improving the cytokine storm effect. Overall, curcumin supplementation may offer a safe and effective option for improving COVID-19 disease outcomes.
Despite the ongoing vaccination efforts, there is still an urgent need for safe and effective treatments to help curb the debilitating effects of COVID-19 disease. This systematic review aimed to investigate the efficacy of supplemental curcumin treatment on clinical outcomes and inflammation-related biomarker profiles in COVID-19 patients. We searched PubMed, Scopus, Web of Science, EMBASE, ProQuest, and Ovid databases up to 30 June 2021 to find studies that assessed the effects of curcumin-related compounds in mild to severe COVID-19 patients. Six studies were identified which showed that curcumin supplementation led to a significant decrease in common symptoms, duration of hospitalization and deaths. In addition, all of these studies showed that the intervention led to amelioration of cytokine storm effects thought to be a driving force in severe COVID-19 cases. This was seen as a significant (p < 0.05) decrease in proinflammatory cytokines such as IL1 beta and IL6, with a concomitant significant (p < 0.05) increase in anti-inflammatory cytokines, including IL-10, IL-35 and TGF-alpha. Taken together, these findings suggested that curcumin exerts its beneficial effects through at least partial restoration of pro-inflammatory/anti-inflammatory balance. In conclusion, curcumin supplementation may offer an efficacious and safe option for improving COVID-19 disease outcomes. We highlight the point that future clinical studies of COVID-19 disease should employ larger cohorts of patients in different clinical settings with standardized preparations of curcumin-related compounds.
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