期刊
NUTRIENTS
卷 14, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/nu14030446
关键词
adipogenesis; AMPK; brown adipose tissue; FNDC5; PGC-1 alpha; SIRT1
资金
- INNOPOLIS Foundation of Korea [2020-DD-RD-0420-01-201]
- KIOM of Korea [KSN2022310]
This study found that BS21 has anti-obesity and antihyperlipidemic activities in high-fat diet-induced obese mice by increasing thermogenesis and energy expenditure, and regulating lipid metabolism.
This study examined the anti-obesity effects of a Phyllostachys pubescens (leaf) and Scutellaria baicalensis root mixture (BS21), and its underlying mechanisms of action, in high-fat diet (HFD)-induced obese mice. Mice were fed a HFD with BS21 (100, 200, or 400 mg/kg) for 9 weeks. BS21 reduced body weight, white adipose tissue (WAT) and liver weights, liver lipid accumulation, and adipocyte size. Additionally, BS21 reduced serum concentrations of non-esterified fatty acid, triglyceride, glucose, lactate dehydrogenase, low-density lipoprotein cholesterol, total cholesterol, leptin, and insulin growth factor 1, but elevated the adiponectin concentrations. Furthermore, BS21 suppressed the mRNA levels of lipogenesis-related proteins, such as peroxisome proliferator-activated receptor (PPAR) gamma, SREBP-1c, C/EBP-alpha, fatty acid synthase, and leptin, but increased the mRNA gene expression of lipolysis-related proteins, such as PPAR-alpha, uncoupling protein (UCP) 2, adiponectin, and CPT1b, in WAT. In addition, BS21 increased the cold-stimulated adaptive thermogenesis and UCP1 protein expression with AMPK activation in adipose tissue. Furthermore, BS21 increased the WAT and mRNA expression of energy metabolism-related proteins SIRT1, PGC-1 alpha, and FNDC5/irisin in the quadriceps femoris muscle. These results suggest that BS21 exerts anti-obesity and antihyperlipidemic activities in HFD-induced obese mice by increasing the thermogenesis and energy expenditure, and regulating lipid metabolism. Therefore, BS21 could be useful for preventing and treating obesity and its related metabolic diseases.
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